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Integration of thermal and osmotic regulation of water homeostasis: the role of TRPV channels
Journal article   Open access   Peer reviewed

Integration of thermal and osmotic regulation of water homeostasis: the role of TRPV channels

Celia D Sladek and Alan Kim Johnson
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.305(7), pp.R669-678
10/01/2013
DOI: 10.1152/ajpregu.00270.2013
PMCID: PMC3798796
PMID: 23883678
url
https://doi.org/10.1152/ajpregu.00270.2013View
Published (Version of record) Open Access

Abstract

Maintenance of body water homeostasis is critical for preventing hyperthermia, because evaporative cooling is the most efficient means of dissipating excess body heat. Water homeostasis is achieved by regulation of water intake and water loss by the kidneys. The former is achieved by sensations of thirst that motivate water acquisition, whereas the latter is regulated by the antidiuretic action of vasopressin. Vasopressin secretion and thirst are stimulated by increases in the osmolality of the extracellular fluid as well as decreases in blood pressure and/or blood volume, signals that are precipitated by water depletion associated with the excess evaporative water loss required to prevent hyperthermia. In addition, they are stimulated by increases in body temperature. The sites and molecular mechanisms involved in integrating thermal and osmotic regulation of thirst and vasopressin secretion are reviewed here with a focus on the role of the thermal and mechanosensitive transient receptor potential-vanilloid (TRPV) family of ion channels.
 Diuresis Humans Body Temperature Regulation Awards and Prizes Drinking Vasopressins - metabolism Thermosensing Brain - metabolism Body Water - metabolism Mechanotransduction, Cellular TRPV Cation Channels - metabolism Kidney - metabolism Animals Neural Pathways - metabolism Water-Electrolyte Balance Thirst

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