Journal article
Integrin-mediated resistance to epidermal growth factor receptor-targeted therapy: an inflammatory situation
Breast cancer research : BCR, Vol.16(5), pp.1-3
09/23/2014
DOI: 10.1186/s13058-014-0448-0
PMCID: PMC4728772
PMID: 25255930
Abstract
Targeting the function of epidermal growth factor receptor (EGFR) has failed as an effective clinical option for breast cancer. Understanding the drivers of inherent resistance has been a challenge. One possible mechanism is the acquisition of stem-like properties through the process of epithelial-mesenchymal transition. A recent study by Seguin and colleagues adds to our understanding of this process by demonstrating a functional role for unligated αvβ3 integrin in mediating a stem-like phenotype and facilitating resistance to EGFR-targeted therapy via enhanced downstream coupling to a KRAS:RalB:NF-κB pathway. Importantly, the identified mechanism may reveal a possible strategy for sensitizing breast cancer cells to EGFR-targeted therapies.
Details
- Title: Subtitle
- Integrin-mediated resistance to epidermal growth factor receptor-targeted therapy: an inflammatory situation
- Creators
- Wells S Brown - Purdue University West LafayetteMichael K Wendt - Purdue University West Lafayette
- Resource Type
- Journal article
- Publication Details
- Breast cancer research : BCR, Vol.16(5), pp.1-3
- DOI
- 10.1186/s13058-014-0448-0
- PMID
- 25255930
- PMCID
- PMC4728772
- NLM abbreviation
- Breast Cancer Res
- ISSN
- 1465-5411
- eISSN
- 1465-542X
- Publisher
- BioMed Central
- Language
- English
- Date published
- 09/23/2014
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984459628102771
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