Integrin signaling to the actin cytoskeleton

Kris A DeMali; Krister Wennerberg; Keith Burridge

doi:10.1016/S0955-0674(03)00109-1

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Integrin signaling to the actin cytoskeleton

Journal article

Open access

Peer reviewed

Integrin signaling to the actin cytoskeleton

Kris A DeMali, Krister Wennerberg and Keith Burridge

Current opinion in cell biology, Vol.15(5), pp.572-582

2003

DOI: 10.1016/S0955-0674(03)00109-1

PMID: 14519392

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Abstract

Integrin engagement stimulates the activity of numerous signaling molecules, including the Rho family of GTPases, tyrosine phosphatases, cAMP-dependent protein kinase and protein kinase C, and stimulates production of PtdIns(4,5) P 2. Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion.

SHPS-1

ILK

CHO

cAMP

GDI

PTP

WASP

WAVE

Arp2/3

PINCH

SFK

DOCK180

PtdIns(4,5)P 2

PIP 5-kinase

PKA

SCAR

GEF

PKC

ECM

FAK

SHP-2

GAP

Pakistan

Crk

MAP

PIX

Details

Title: Subtitle: Integrin signaling to the actin cytoskeleton
Creators: Kris A DeMali
Krister Wennerberg
Keith Burridge
Resource Type: Journal article
Publication Details: Current opinion in cell biology, Vol.15(5), pp.572-582
DOI: 10.1016/S0955-0674(03)00109-1
PMID: 14519392
NLM abbreviation: Curr Opin Cell Biol
ISSN: 0955-0674
eISSN: 1879-0410
Publisher: Elsevier Ltd
Language: English
Date published: 2003
Academic Unit: Dermatology; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
Record Identifier: 9984024403502771

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