Journal article
Intensity-modulated x-ray (IMXT) versus proton (IMPT) therapy for theragnostic hypoxia-based dose painting
Physics in medicine & biology, Vol.53(15), pp.4153-4167
08/07/2008
DOI: 10.1088/0031-9155/53/15/010
PMCID: PMC2695924
PMID: 18635895
Abstract
In this work the abilities of intensity-modulated x-ray therapy (IMXT) and intensity-modulated proton therapy (IMPT) to deliver boosts based on theragnostic imaging were assessed. Theragnostic imaging is the use of functional or molecular imaging data for prescribing radiation dose distributions. Distal gradient tracking, an IMPT method designed for the delivery of non-uniform dose distributions, was assessed. Dose prescriptions for a hypoxic region in a head and neck squamous cell carcinoma patient were designed to either uniformly boost the region or redistribute the dose based on positron emission tomography (PET) images of the (61)Cu(II)-diacetyl-bis(N(4)-methylthiosemicarbazone) ((61)Cu-ATSM) hypoxia surrogate. Treatment plans for the prescriptions were created for four different delivery methods: IMXT delivered with step-and-shoot and with helical tomotherapy, and IMPT delivered with spot scanning and distal gradient tracking. IMXT and IMPT delivered comparable dose distributions within the boost region for both uniform and redistributed theragnostic boosts. Normal tissue integral dose was lower by a factor of up to 3 for IMPT relative to the IMXT. For all delivery methods, the mean dose to the nearby organs at risk changed by less than 2 Gy for redistributed versus uniform boosts. The distal gradient tracking method resulted in comparable plans to the spot scanning method while reducing the number of proton beam spots by a factor of over 3.
Details
- Title: Subtitle
- Intensity-modulated x-ray (IMXT) versus proton (IMPT) therapy for theragnostic hypoxia-based dose painting
- Creators
- Ryan T Flynn - Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53703, USA. flynnrt@gmail.comStephen R BowenSøren M BentzenT Rockwell MackieRobert Jeraj
- Resource Type
- Journal article
- Publication Details
- Physics in medicine & biology, Vol.53(15), pp.4153-4167
- DOI
- 10.1088/0031-9155/53/15/010
- PMID
- 18635895
- PMCID
- PMC2695924
- NLM abbreviation
- Phys Med Biol
- ISSN
- 0031-9155
- eISSN
- 1361-6560
- Publisher
- England
- Grant note
- P01 CA088960-01A10001 / NCI NIH HHS T32 CA009206 / NCI NIH HHS P01 CA088960 / NCI NIH HHS P30 CA14520 / NCI NIH HHS P30 CA014520 / NCI NIH HHS P01 CA88960 / NCI NIH HHS T32 CA009206-30 / NCI NIH HHS T32 CA09206 / NCI NIH HHS
- Language
- English
- Date published
- 08/07/2008
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984046813602771
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