Intensive Menstrual Bleeding Successfully Treated With Recombinant Factor VIIa in Glanzmann Thrombasthenia

Yasemin Işık Balcı; Aysun Karabulut; Sibel Kabukcu; Ismail Sari; Ali Keskin

doi:10.1177/1076029610364518

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Intensive Menstrual Bleeding Successfully Treated With Recombinant Factor VIIa in Glanzmann Thrombasthenia

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Intensive Menstrual Bleeding Successfully Treated With Recombinant Factor VIIa in Glanzmann Thrombasthenia

Yasemin Işık Balcı, Aysun Karabulut, Sibel Kabukcu, Ismail Sari and Ali Keskin

Clinical and applied thrombosis/hemostasis, Vol.17(4), pp.320-322

08/01/2011

DOI: 10.1177/1076029610364518

PMID: 20460355

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Abstract

Glanzmann thrombasthenia (GT) is a rare inherited qualitative platelet disorder due to the deficiency or defect of platelet membrane glycoprotein (GP) IIb/IIIa complex. Symptoms include purpura, petechiae, bruising, gingival bleeding, epistaxis, and menorrhagia. Platelet transfusion is considered the standard therapy for securing hemostasis in patients with GT when local measures and antifibrinolytic agents are inadequate. However, repeated platelet transfusions may result in GP IIb/IIIa and/or human leukocyte antigen (HLA) immunization and development of platelet refractoriness. Recombinant factor VIIa (rFVIIa) has been introduced as therapeutic alternative and has been suggested to be effective. Recombinant factor VIIa is indicated in Europe for the treatment of GT refractory of platelet transfusion. In previous studies, rFVIIa has been used in the prophylactic treatment of bleeding in patients with GT undergoing pelvic surgery, cesarean section, and vaginal delivery. In this article, we present a case of intensive menstrual bleeding refractory to previous antifibrinolytic agents and platelet transfusions but which responded well to treatment with rFVIIa. To our knowledge, there is no study or reported case in the literature reporting successful use of rFVIIa in a patient with excessive menstrual bleeding due to GT.

Hematology

Cardiovascular System & Cardiology

Life Sciences & Biomedicine

Peripheral Vascular Disease

Science & Technology

Details

Title: Subtitle: Intensive Menstrual Bleeding Successfully Treated With Recombinant Factor VIIa in Glanzmann Thrombasthenia
Creators: Yasemin Işık Balcı - Denizli Devlet Hastanesi
Aysun Karabulut - Denizli Devlet Hastanesi
Sibel Kabukcu - Pamukkale University
Ismail Sari - Pamukkale University
Ali Keskin - Pamukkale University
Resource Type: Journal article
Publication Details: Clinical and applied thrombosis/hemostasis, Vol.17(4), pp.320-322
DOI: 10.1177/1076029610364518
PMID: 20460355
NLM abbreviation: Clin Appl Thromb Hemost
ISSN: 1076-0296
eISSN: 1938-2723
Publisher: Sage
Number of pages: 3
Grant note: Denizli State Hospital Pamukkale University, Faculty of Medicine; Pamukkale University
Language: English
Date published: 08/01/2011
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9985123695502771

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