Journal article
Inter-rater reliability of muscle ultrasonography performed by multidisciplinary novice sonographers in the evaluation of critically ill patients with acute kidney injury requiring continuous kidney replacement therapy
Renal failure, Vol.47(1), 2472990
12/2025
DOI: 10.1080/0886022X.2025.2472990
PMCID: PMC11899198
PMID: 40069097
Abstract
Early diagnosis of muscle wasting in critically ill patients with acute kidney injury requiring continuous kidney replacement therapy (AKI-CKRT) may improve outcomes
timely rehabilitation and nutrition. Muscle ultrasound (MUS) has recently gained traction for assessing muscle atrophy in the intensive care unit (ICU) but requires training to achieve reproducibility. We evaluated the inter-rater reliability of MUS in patients with AKI-CKRT performed by multidisciplinary raters including nephrologists. Two blinded independent raters used portable ultrasound to acquire images of the rectus femoris (RF). All raters were clinicians routinely caring for patients with CKRT in the ICU and were initially novices in MUS. They underwent three two-hour teleconference training sessions in MUS led by an experienced physiotherapist. Inter-rater reliability was evaluated with intraclass correlation coefficients (ICCs) [95% confidence interval] using a two-way random-effects model. We analyzed 54 MUS images (27 pairs) from nine patients at baseline (
= 16), day 3 (
= 6), day 7 (
= 8), ICU discharge (
= 10), hospital discharge (
= 10), and 1-3 months after discharge (
= 4). The mean (±standard deviation) values of RF thickness, cross-sectional area, and echointensity were 1.7 ± 1.4 cm, 4.6 ± 2.7 cm
, and 84.0 ± 17.7 AU, respectively. Reliability was excellent for RF thickness (ICC = 0.96 [0.91-0.98],
< 0.001) and cross-sectional area (ICC = 0.92 [0.83-0.96],
< 0.001) but poor for echointensity (ICC = 0.41 [0.04-0.68],
< 0.05). These results demonstrate reliable assessment of muscle size in patients with AKI-CKRT using ultrasound performed by multidisciplinary novice sonographers trained
teleconference, suggesting that this methodology may be useful in future studies of muscle wasting in patients with AKI-CKRT.
Details
- Title: Subtitle
- Inter-rater reliability of muscle ultrasonography performed by multidisciplinary novice sonographers in the evaluation of critically ill patients with acute kidney injury requiring continuous kidney replacement therapy
- Creators
- Felipe González-Seguel - University of KentuckyVinh Q Tran - University of New MexicoChaitanya Anil Pal - University of New MexicoZan T Shareef - University of New MexicoHayley P Israel - University of New MexicoArimitsu Horikawa-Strakovsky - University of KentuckyYuan Wen - University of KentuckyBenjamin R Griffin - University of Iowa Hospitals and ClinicsJavier A Neyra - University of Alabama at BirminghamJ Pedro Teixeira - University of New MexicoKirby P Mayer - University of Kentucky
- Resource Type
- Journal article
- Publication Details
- Renal failure, Vol.47(1), 2472990
- DOI
- 10.1080/0886022X.2025.2472990
- PMID
- 40069097
- PMCID
- PMC11899198
- NLM abbreviation
- Ren Fail
- ISSN
- 0886-022X
- eISSN
- 1525-6049
- Publisher
- TAYLOR & FRANCIS LTD
- Grant note
- R01 DK128208 / NIDDK NIH HHS U24 TR002260 / NCATS NIH HHS K23 AR079583 / NIAMS NIH HHS P30 DK079337 / NIDDK NIH HHS
- Language
- English
- Date published
- 12/2025
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984801668402771
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