Journal article
Interaction Between Serotonin Transporter Polymorphism (5-HTTLPR) and Stressful Life Events in Adolescents’ Trajectories of Anxious/Depressed Symptoms
Developmental psychology, Vol.48(5), pp.1463-1475
09/2012
DOI: 10.1037/a0027471
PMCID: PMC3404160
PMID: 22390669
Abstract
Caspi et al. (2003)
found an interaction between the serotonin transporter polymorphism gene (
5-HTTLPR
) and stressful life events on depression. Subsequent attempts to replicate have been inconsistent. The present research included long allele variants modified by SNP
rs25531
and tested the interaction on adolescents’ trajectories of anxious/depressed symptoms, with consideration of possible age effects. Adolescents (
N
= 574), of whom 436 were genotyped, were followed from ages 12 to 17. Analyses demonstrated a G × E interaction in predicting the development of anxious/depressed symptoms. Specifically, adolescents with lower serotonin transcriptional efficiency (TE) genotypes whose mothers reported more stressful events were reported to show more anxious/depressed symptoms and greater increases in the development of symptoms of anxiety and depression than were higher TE adolescents, particularly at ages 16 and 17. Interactions did not differ by gender. Findings demonstrate that stress may affect adolescents’ likelihood of experiencing anxious/depressed symptoms when they have a low serotonin TE (A/G-modified
5-HTTLPR
) genotype and suggest that the vulnerability may be stronger in late than early adolescence.
Details
- Title: Subtitle
- Interaction Between Serotonin Transporter Polymorphism (5-HTTLPR) and Stressful Life Events in Adolescents’ Trajectories of Anxious/Depressed Symptoms
- Creators
- Isaac T Petersen - Department of Psychological and Brain Sciences, Indiana UniversityJohn E Bates - Department of Psychological and Brain Sciences, Indiana UniversityJackson A Goodnight - Department of Psychology, University of DaytonKenneth A Dodge - Center for Child and Family Policy, Duke UniversityJennifer E Lansford - Center for Child and Family Policy, Duke UniversityGregory S Pettit - Department of Human Development and Family Studies, Auburn UniversityShawn J Latendresse - Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth UniversityDanielle M Dick - Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University
- Resource Type
- Journal article
- Publication Details
- Developmental psychology, Vol.48(5), pp.1463-1475
- DOI
- 10.1037/a0027471
- PMID
- 22390669
- PMCID
- PMC3404160
- NLM abbreviation
- Dev Psychol
- ISSN
- 0012-1649
- eISSN
- 1939-0599
- Grant note
- T32 HD007475-17 || HD / National Institute of Child Health & Human Development : NICHD
- Language
- English
- Date published
- 09/2012
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Center for Social Science Innovation
- Record Identifier
- 9984065381802771
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