Interaction between 5-HTTLPR polymorphism and abuse history on adolescent African-American females' condom use behavior following participation in an HIV prevention intervention

Jessica M Sales; Ralph J DiClemente; Gene H Brody; Robert A Philibert; Eve Rose

doi:10.1007/s11121-013-0378-6

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Interaction between 5-HTTLPR polymorphism and abuse history on adolescent African-American females' condom use behavior following participation in an HIV prevention intervention

Journal article

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Peer reviewed

Interaction between 5-HTTLPR polymorphism and abuse history on adolescent African-American females' condom use behavior following participation in an HIV prevention intervention

Jessica M Sales, Ralph J DiClemente, Gene H Brody, Robert A Philibert and Eve Rose

Prevention science, Vol.15(3), pp.257-267

06/2014

DOI: 10.1007/s11121-013-0378-6

PMCID: PMC3769489

PMID: 23479192

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Abstract

Not everyone exposed to an efficacious human immunodeficiency virus (HIV) intervention will reduce sexual risk behaviors, yet little is known about factors associated with "failure to change" high-risk sexual behaviors post-intervention. History of abuse and polymorphisms in the serotonin transporter gene (5-HTT) may be associated with non-change. The current study sought to identify genetic, life history, and psychosocial factors associated with adolescents' failure to change condom use behaviors post-participation in an HIV prevention intervention. A sub-set of participants from a clinic-based sample of adolescent African-American females (N = 254) enrolled in a randomized trial of an HIV-prevention was utilized for the current study. Forty-four percent did not increase their condom use from baseline levels 6 months after participating in the sexually transmitted infection (STI)/HIV prevention intervention. In multivariable logistic regression analysis, an interaction between abuse and 5-HTTLPR group was significantly associated with non-change status, along with partner communication frequency scores at follow-up. Follow-up tests found that having a history of abuse was significantly associated with greater odds of non-change in condom use post-intervention for only those with the s allele. For those with ll allele, participants with higher partner communication frequency scores were at decreased odds of non-change in condom use post-intervention. Thus, STI/HIV interventions for adolescent females may consider providing a more in-depth discussion and instruction on how to manage and overcome fear or anxiety related to being assertive in sexual decisions or sexual situations. Doing so may improve the efficacy of STI/HIV prevention programs for adolescent women who have experienced abuse in their lifetime.

HIV Infections - prevention & control

Humans

Risk Factors

Battered Women - psychology

African Americans

Genotype

Sexually Transmitted Diseases - prevention & control

Substance-Related Disorders - complications

Polymorphism, Genetic

Sexual Behavior - psychology

Young Adult

Serotonin Plasma Membrane Transport Proteins - genetics

Risk-Taking

Adolescent

Alleles

Female

Condoms - utilization

Georgia

Parent-Child Relations

Details

Title: Subtitle: Interaction between 5-HTTLPR polymorphism and abuse history on adolescent African-American females' condom use behavior following participation in an HIV prevention intervention
Creators: Jessica M Sales - Department of Behavioral Sciences and Health Education, Rollins School of Public Health at Emory University, 1518 Clifton Rd., NE, Room 570, Atlanta, GA, 30322, USA, jmcderm@emory.edu
Ralph J DiClemente
Gene H Brody
Robert A Philibert
Eve Rose
Resource Type: Journal article
Publication Details: Prevention science, Vol.15(3), pp.257-267
DOI: 10.1007/s11121-013-0378-6
PMID: 23479192
PMCID: PMC3769489
NLM abbreviation: Prev Sci
ISSN: 1573-6695
eISSN: 1573-6695
Publisher: United States
Grant note: P30 DA027827 / NIDA NIH HHS P03 DA027827 / NIDA NIH HHS K01 MH085506 / NIMH NIH HHS R01 MH070537 / NIMH NIH HHS
Language: English
Date published: 06/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003912702771

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