Interaction between smoking and body mass index and risk of oral clefts

George L Wehby; Lina M. Moreno Uribe; Allen J Wilcox; Kaare Christensen; Paul A Romitti; Ronald G Munger; Rolv T Lie

doi:10.1016/j.annepidem.2016.11.009

Back

Interaction between smoking and body mass index and risk of oral clefts

Journal article

Peer reviewed

Interaction between smoking and body mass index and risk of oral clefts

George L Wehby, Lina M. Moreno Uribe, Allen J Wilcox, Kaare Christensen, Paul A Romitti, Ronald G Munger and Rolv T Lie

Annals of epidemiology, Vol.27(2), pp.103-107.e2

02/2017

DOI: 10.1016/j.annepidem.2016.11.009

PMCID: PMC5315269

PMID: 28202134

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/5315269View

Open Access

Abstract

To examine maternal smoking and body mass index (BMI) interactions in contributing to risk of oral clefts. We studied 4935 cases and 10,557 controls from six population-based studies and estimated a pooled logistic regression of individual-level data, controlling for study fixed effects and individual-level risk factors. We found a significant negative smoking–BMI interaction, with cleft risk with smoking generally declining with higher BMI. For all clefts combined, the odds ratio for smoking was 1.61 (95% confidence interval [CI]: 1.39–1.86) at BMI 17 (underweight), 1.47 (95% CI: 1.34–1.62) at BMI 22 (normal weight), 1.35 (95% CI: 1.22–1.48) at BMI 27 (overweight), 1.21 (95% CI: 1.04–1.41) at BMI 33 (obese), and 1.13 (95% CI: 0.92–1.38) at BMI 37 (very obese). A negative interaction was also observed for isolated clefts and across cleft types but was more pronounced for cleft lip only and cleft palate only. Our findings suggest that the risk of oral clefts associated with maternal smoking is largest among underweight mothers, although the smoking–BMI interaction is strongest for cleft lip only and cleft palate only. BMI was not protective for the effects of smoking; a clinically relevant increase in smoking-related cleft risk was still present among heavier women.

Obesity

Body mass index

Cleft palate

Cleft lip

Body weight

Smoking

Details

Title: Subtitle: Interaction between smoking and body mass index and risk of oral clefts
Creators: George L Wehby - Department of Health Management and Policy, University of Iowa, Iowa City
Lina M. Moreno Uribe - Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City
Allen J Wilcox - National Institutes of Health, National Institute of Environmental Health Sciences, Epidemiology Branch, Durham, NC
Kaare Christensen - Department of Epidemiology, University of Southern Denmark, Odense, Denmark
Paul A Romitti - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City
Ronald G Munger - Center for Epidemiologic Studies, Utah State University, Logan
Rolv T Lie - Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
Resource Type: Journal article
Publication Details: Annals of epidemiology, Vol.27(2), pp.103-107.e2
DOI: 10.1016/j.annepidem.2016.11.009
PMID: 28202134
PMCID: PMC5315269
NLM abbreviation: Ann Epidemiol
ISSN: 1047-2797
eISSN: 1873-2585
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000072, name: National Institute of Dental and Craniofacial Research, award: R01 DE020895
Language: English
Date published: 02/2017
Academic Unit: Preventive and Community Dentistry; Orthodontics; Health Management and Policy; Epidemiology; Economics; Biostatistics; Craniofacial Anomalies Research Center; Public Policy Center (Archive); Dental Research
Record Identifier: 9983995040502771

Metrics

15 Record Views

7 Times Cited - Web of Science