Journal article
Interaction of Cardiopulmonary and Somatic Reflexes in Humans
The Journal of clinical investigation, Vol.65(6), pp.1491-1497
06/1980
DOI: 10.1172/JCI109814
PMCID: PMC371488
PMID: 7410553
Abstract
Activation of cardiopulmonary receptors with vagal afferents results predominantly in reflex inhibition of efferent sympathetic activity, whereas activation of somatic receptors reflexly increases sympathetic activity to the heart and circulation. Previous studies in experimental animals indicate that there is an important interaction between these excitatory and inhibitory reflexes in the control of the renal circulation.\nThe purpose of this study was to determine whether there is a similar interaction between somatic and cardiopulmonary reflexes in humans. The activity of the cardiopulmonary receptors was altered (reduced) with lower body negative pressure (−5 mm Hg), which causes a decrease in cardiac filling pressure and a small reflex increase in forearm vascular resistance without accompanying changes in arterial pressure. Activation of somatic receptors by isometric handgrip for 2 min at 10 and 20% of maximum voluntary contraction resulted in reflex vasoconstriction in the nonexercising arm. Lower body negative pressure at −5 mm Hg produced a threefold augmentation in the forearm vasoconstrictor response to isometric handgrip in the nonexercising arm. This increase in resistance was significantly greater (\nP\n< 0.05) than the algebraic sum of the increases in resistance resulting from lower body suction alone plus isometric handgrip alone. Furthermore, it occurred despite a greater rise in arterial pressure, which would be expected to decrease forearm vascular resistance through activation of arterial baroreceptors and through passive dilatation of forearm vessels. Thus, removal of the inhibitory influence of cardiopulmonary receptors by pooling blood in the lower extremities enhances the somatic reflex. These data suggest an interaction between cardiopulmonary and somatic reflexes in the control of forearm vascular resistance in man.
Details
- Title: Subtitle
- Interaction of Cardiopulmonary and Somatic Reflexes in Humans
- Creators
- John L Walker - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242Francois M Abboud - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242Allyn L Mark - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242Marc D Thames - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.65(6), pp.1491-1497
- Publisher
- American Society for Clinical Investigation
- DOI
- 10.1172/JCI109814
- PMID
- 7410553
- PMCID
- PMC371488
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 06/1980
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025339902771
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