Interaction of Gβγ with RACK1 and other WD40 repeat proteins

Songhai Chen; Bryan D Spiegelberg; Fang Lin; Edward J Dell; Heidi E Hamm

doi:10.1016/j.yjmcc.2004.04.019

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Interaction of Gβγ with RACK1 and other WD40 repeat proteins

Journal article

Peer reviewed

Interaction of Gβγ with RACK1 and other WD40 repeat proteins

Songhai Chen, Bryan D Spiegelberg, Fang Lin, Edward J Dell and Heidi E Hamm

Journal of molecular and cellular cardiology, Vol.37(2), pp.399-406

2004

DOI: 10.1016/j.yjmcc.2004.04.019

PMID: 15276010

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Abstract

Heterotrimeric G-proteins, composed of Gα and Gβγ subunits, transmit numerous and diverse extracellular stimuli via a large family of heptahelical cell-surface receptors to various intracellular effector molecules. The Gβγ subunit plays a central role in G-protein signaling. The Gβ subunit belongs to a large family of WD40 repeat proteins, which adopt a circular β-bladed propeller structure. This unique structural feature confers interactions of Gβγ with a variety of proteins to play diverse functions. Intriguingly, we recently found that Gβγ can interact with three other WD40 repeat proteins, receptor for activated C kinase 1 (RACK1), dynein intermediate chain-1A and a protein of unknown function. This raises the following questions: are interactions among WD40 proteins a common theme and does the formation of a WD40–WD40 repeat protein complex constitute a protein scaffold for integrating signals from different cellular processes. We are beginning to address these issues by studying the interaction between Gβγ and RACK1. Here we will describe the molecular mechanism underlying this interaction and the implications of the interaction on the signal transduction of G-protein and RACK1.

RACK1

Heterotrimeric G-protein βγ subunits

WD40 repeat proteins

Dynein intermediate chain

Details

Title: Subtitle: Interaction of Gβγ with RACK1 and other WD40 repeat proteins
Creators: Songhai Chen
Bryan D Spiegelberg
Fang Lin
Edward J Dell
Heidi E Hamm
Resource Type: Journal article
Publication Details: Journal of molecular and cellular cardiology, Vol.37(2), pp.399-406
DOI: 10.1016/j.yjmcc.2004.04.019
PMID: 15276010
NLM abbreviation: J Mol Cell Cardiol
ISSN: 0022-2828
eISSN: 1095-8584
Publisher: Elsevier Ltd
Language: English
Date published: 2004
Academic Unit: Anatomy and Cell Biology; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040289102771

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