Interaction of a subanaesthetic concentration of isoflurane with midazolam: effects on responsiveness, learning and memory

M M Ghoneim; R I Block; V J Dhanaraj

doi:10.1093/bja/80.5.581

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Interaction of a subanaesthetic concentration of isoflurane with midazolam: effects on responsiveness, learning and memory

Journal article

Open access

Peer reviewed

Interaction of a subanaesthetic concentration of isoflurane with midazolam: effects on responsiveness, learning and memory

M M Ghoneim, R I Block and V J Dhanaraj

British journal of anaesthesia : BJA, Vol.80(5), pp.581-587

05/1998

DOI: 10.1093/bja/80.5.581

PMID: 9691858

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Abstract

There are situations in which "light" anaesthesia combined with neuromuscular block is the only anaesthetic regimen that can be tolerated safely by the patient. Benzodiazepines have hypnotic and specific amnesic effects. Therefore, we have examined the interaction of midazolam with a subanaesthetic dose of isoflurane (0.2% end-expired concentration) in 28 healthy volunteers. Thereafter, 15 subjects received midazolam 0.03 mg kg-1 i.v. and 13 subjects received midazolam 0.06 mg kg-1 in a random, double-blind manner. Word lists were administered and response to commands was tested before and after administration of midazolam. After 1 h of recovery, memory for word lists was tested by word completion, free recall and forced choice recognition tasks. After administration of midazolam, recall and, to a lesser degree, implicit memory were absent. Recognition was also absent after administration of midazolam 0.06 mg kg-1 and at the 3-min and 15-min assessments after administration of midazolam 0.03 mg kg-1. Responsiveness was more frequent with midazolam 0.03 mg kg-1 than with 0.06 mg kg-1 and increased over time. We conclude that a larger dose of midazolam or isoflurane, or both, may be necessary to abolish responsiveness.

Memory - drug effects

Anesthetics, Inhalation - pharmacology

Double-Blind Method

Isoflurane - pharmacology

Awareness - drug effects

Learning - drug effects

Humans

Anti-Anxiety Agents - pharmacology

Male

Mental Recall - drug effects

Dose-Response Relationship, Drug

Drug Interactions

Time Factors

Adult

Female

Midazolam - pharmacology

Details

Title: Subtitle: Interaction of a subanaesthetic concentration of isoflurane with midazolam: effects on responsiveness, learning and memory
Creators: M M Ghoneim - Department of Anesthesia, College of Medicine, University of Iowa, Iowa City 52242, USA
R I Block
V J Dhanaraj
Resource Type: Journal article
Publication Details: British journal of anaesthesia : BJA, Vol.80(5), pp.581-587
Publisher: England
DOI: 10.1093/bja/80.5.581
PMID: 9691858
ISSN: 0007-0912
eISSN: 1471-6771
Language: English
Date published: 05/1998
Academic Unit: Iowa Neuroscience Institute; Anesthesia
Record Identifier: 9984007181102771

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