Journal article
Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans
The Journal of clinical investigation, Vol.87(6), pp.1953-1957
06/1991
DOI: 10.1172/JCI115221
PMCID: PMC296947
PMID: 2040688
Abstract
Animal studies have demonstrated that activation of the baroreflex by increases in arterial pressure inhibits cardiovascular and ventilatory responses to activation of peripheral chemoreceptors (PC) with hypoxia. In this study, we examined the influences of baroreflex activation on the sympathetic response to stimulation of PC and central chemoreceptors in humans. PC were stimulated by hypoxia (10% O2/90% N2) (n = 6) and central chemoreceptors by hypercapnia (7% CO2/93% O2) (n = 6). Responses to a cold pressor stimulus were also obtained as an internal reflex control to determine the selectivity of the interactive influence of baroreflex activation. Baroreflex activation was achieved by raising mean blood pressure by greater than 10 mmHg with intravenous infusion of phenylephrine (PE). Sympathetic nerve activity (SNA) to muscle was recorded from a peroneal nerve (microneurography). During hypoxia alone, SNA increased from 255 +/- 92 to 354 +/- 107 U/min (P less than 0.05). During PE alone, mean blood pressure increased and SNA decreased to 87 +/- 45 U/min (P less than 0.05). With hypoxia during baroreflex activation with PE, SNA did not increase (50 +/- 23 U/min). During hypercapnia alone, SNA increased from 116 +/- 39 to 234 +/- 72 U/min (P less than 0.01). Hypercapnia during baroreflex activation with PE increased SNA from 32 +/- 25 U/min during PE alone to 61 +/- 26 U/min during hypercapnia and PE (P less than 0.05). Like hypercapnia (but unlike hypoxia) the cold pressor test also increased SNA during PE. We conclude that baroreflex activation selectively abolishes the SNA response to hypoxia but not to hypercapnia or the cold pressor test. The inhibitory interaction of the baroreflex and the peripheral chemoreflex may be explained by convergence of baroreceptor and peripheral chemoreceptor afferents on neurons in the medulla.
Details
- Title: Subtitle
- Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans
- Creators
- Virend K Somers - Department of Internal Medicine, University of Iowa, Iowa City 55242Allyn L MarkFrancois M Abboud
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.87(6), pp.1953-1957
- Publisher
- United States
- DOI
- 10.1172/JCI115221
- PMID
- 2040688
- PMCID
- PMC296947
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Grant note
- HL-24962 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS
- Language
- English
- Date published
- 06/1991
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025447202771
Metrics
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