Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake

Juliana Irani Fratucci De Gobbi; Laurival Antonio De Luca; Alan Kim Johnson; José Vanderlei Menani

doi:10.1152/ajpregu.2001.280.5.R1301

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Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake

Journal article

Peer reviewed

Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake

Juliana Irani Fratucci De Gobbi, Laurival Antonio De Luca, Alan Kim Johnson and José Vanderlei Menani

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.280(5), pp.R1301-R1307

05/01/2001

DOI: 10.1152/ajpregu.2001.280.5.R1301

PMID: 11294747

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Abstract

Serotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. In this study, we investigated interactions between 5-HT and CCK into the LPBN to control water and NaCl intake. Male Holtzman rats with cannulas implanted bilaterally in the LPBN were treated with furosemide + captopril to induce water and NaCl intake. Bilateral LPBN injections of high doses of the 5-HT antagonist methysergide (4 μg) or the CCK antagonist proglumide (50 μg), alone or combined, produced similar increases in water and 1.8% NaCl intake. Low doses of methysergide (0.5 μg) + proglumide (20 μg) produced greater increases in NaCl intake than when they were injected alone. The 5-HT2a/2c agonist 2,5-dimetoxy-4-iodoamphetamine hydrobromide (DOI; 5 μg) into the LPBN reduced water and NaCl intake. After proglumide (50 μg) + DOI treatment, the intake was not different from vehicle treatment. CCK-8 (1 μg) alone produced no effect. CCK-8 combined with methysergide (4 μg) reduced the effect of methysergide on NaCl intake. The data suggest that functional interactions between 5-HT and CCK in the LPBN may be important for exerting inhibitory control of NaCl intake.

Details

Title: Subtitle: Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake
Creators: Juliana Irani Fratucci De Gobbi - Department of Physiology and Pathology, School of Dentistry, Paulista State University (UNESP), 14801 – 903 Araraquara, São Paulo, Brazil; and
Laurival Antonio De Luca - Department of Physiology and Pathology, School of Dentistry, Paulista State University (UNESP), 14801 – 903 Araraquara, São Paulo, Brazil; and
Alan Kim Johnson - Departments of Psychology and Pharmacology and Exercise Science and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242 – 1407
José Vanderlei Menani - Department of Physiology and Pathology, School of Dentistry, Paulista State University (UNESP), 14801 – 903 Araraquara, São Paulo, Brazil; and
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.280(5), pp.R1301-R1307
DOI: 10.1152/ajpregu.2001.280.5.R1301
PMID: 11294747
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Language: English
Date published: 05/01/2001
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213278302771

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