Journal article
Interaction of tetrachlorobiphenyls with isolated rat liver mitochondria
Journal of pharmacobio-dynamics, Vol.8(9), pp.726-732
1985
DOI: 10.1248/bpb1978.8.726
PMID: 2935621
Abstract
A comparative study of the effects of tetrachlorobiphenyls (TCBs) on the succinate-supported respirations of rat liver mitochondria was made, and some differences in effects caused by the different chlorine positions of the biphenyl rings were clarified. The inhibitory actions of 2,3,2',3'-,2,4,2',4'-, and 2,5,2',5'-TCBs on both state 3 and uncoupler-stimulated respirations were potent, while those induced by 2,6,2',6'-, and 3,4,3',4'-TCBs were weak. 2,3,2',3'-,2,4,2',4'-,2,5,2',5'-, and 2,6,2',6'-TCBs stimulated state 4 respiration, but 3,4,3',4'-TCB had very little effect on this respiration. The latent adenosine triphosphatase activity was stimulated by 2,3,2',3'-,2,4,2',4'-, and 2,5,2',5'-TCBs, but 2,6,2',6'-, and 3,4,3',4'-TCBs had no effects. The relationship between these effects and chemical structure of TCBs is discussed.
Details
- Title: Subtitle
- Interaction of tetrachlorobiphenyls with isolated rat liver mitochondria
- Creators
- Yoshimasa NishiharaLarrey W RobertsonFranz OeschKozo Utsumi
- Resource Type
- Journal article
- Publication Details
- Journal of pharmacobio-dynamics, Vol.8(9), pp.726-732
- DOI
- 10.1248/bpb1978.8.726
- PMID
- 2935621
- ISSN
- 0386-846X
- eISSN
- 1881-1353
- Language
- English
- Date published
- 1985
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002415302771
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