Journal article
Interaction of various non-steroidal anti-inflammatories and quinolone antimicrobials on GABA response in rat dissociated hippocampal pyramidal neurons
Brain research, Vol.562(2), pp.329-331
1991
DOI: 10.1016/0006-8993(91)90641-8
PMID: 1663416
Abstract
Interaction of various non-steroidal anti-inflammatory drugs (NSAIDs) and quinolone antimicrobials with γ-aminobutyric acid (GABA)
A receptor-Cl
− channel complex was investigated in rat dissociated hippocampal CA1 neurons by using whole-cell mode path-clamp technique. Neither NSAIDs nor quinolones alone affected the GABA-induced chloride current (I
Cl). In the presence of norfloxacin (NFLX), one of quinolones, some NSAIDs suppressed the GABA response in a concentration-dependent manner. The inhibitory potency of NSAIDs was 4-biphenylacetic acid (BPA), a metabolite offenbufen≫indomethacin=naproxen>mefenamic acid>diclofenac>piroxicam. The results suggest that fenbufen, indomethacin and naproxen in the presence of quinolones may induce the epileptogenic neurotoxicities via pharmacological interaction with GABA
A receptor.
Details
- Title: Subtitle
- Interaction of various non-steroidal anti-inflammatories and quinolone antimicrobials on GABA response in rat dissociated hippocampal pyramidal neurons
- Creators
- Tetsuya ShirasakiNobutoshi HarataToshio NakayeNorio Akaike
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.562(2), pp.329-331
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(91)90641-8
- PMID
- 1663416
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Grant note
- DOI: 10.13039/501100001700, name: Ministry of Education, Culture, Sports, Science and Technology
- Language
- English
- Date published
- 1991
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025681002771
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