Journal article
Interactions Between GB Virus Type C and HIV
Current infectious disease reports, Vol.4(6), pp.550-558
12/2002
DOI: 10.1007/s11908-002-0044-9
PMID: 12433333
Abstract
GB virus C (GBV-C, also known as hepatitis G virus) commonly causes human infection. Genetically, it is closely related to hepatitis C virus, but GBV-C appears to grow primarily in lymphocytes, not hepatocytes. Although it causes persistent infection in about 25% to 50% of infected individuals, numerous studies have failed to connect GBV-C with any disease process. GBV-C is transmitted sexually, parenterally, and vertically, and due to these shared modes of transmission, coinfection is common among HIV-infected individuals. Of 10 studies done of HIV-GBV-C coinfection, eight found a beneficial effect of GBV-C viremia on HIV-related mortality or response to therapy. The mechanism by which GBV-C may improve survival of HIV-positive people is not known; however, in vitro studies suggest that GBV-C inhibits HIV replication, and preliminary data also point toward alterations in cytokine and/or chemokine expression by GBV-C-infected cells.
Details
- Title: Subtitle
- Interactions Between GB Virus Type C and HIV
- Creators
- Sarah L George - Internal Medicine, SW34-P,GH, 200 Hawkins Drive, UIHC, Iowa City, IA 52242, USA. jack-stapleton@uiowa.eduSabina WünschmannJames McCoyJinhua XiangJack T Stapleton
- Resource Type
- Journal article
- Publication Details
- Current infectious disease reports, Vol.4(6), pp.550-558
- DOI
- 10.1007/s11908-002-0044-9
- PMID
- 12433333
- ISSN
- 1523-3847
- eISSN
- 1534-3146
- Language
- English
- Date published
- 12/2002
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094704002771
Metrics
16 Record Views