Journal article
Interactions in nucleus tractus solitarius between right and left carotid sinus nerves
American journal of physiology. Heart and circulatory physiology, Vol.253(5), pp.H1127-H1135
11/01/1987
DOI: 10.1152/ajpheart.1987.253.5.H1127
PMID: 3688256
Abstract
Bilateral carotid sinus nerve stimulation was used as a model for studying cardiovascular afferent interactions in the nucleus tractus solitarius (NTS) region of dorso-medial medulla. Extracellular action potential recordings were made from 69 single units, 33 of which were excited independently by both right and left carotid sinus nerves (CSNs). Fifteen of these were located in NTS. Peak latencies to electrical stimulation of NTS neurons were 17.7 +/- 2.1 ms to ipsilateral CSN and 20.9 +/- 1.5 ms to contralateral CSN. Summation of afferent input was routinely demonstrated. In 10 units in NTS, a conditioning stimulus applied to one CSN caused prolonged inhibition of the response to a test stimulus to the same or the other CSN. The duration of inhibition was dependent on the intensity of the conditioning stimulus, not on prior excitation of the unit by the conditioning stimulus. In five additional excitability testing experiments, we found limited evidence to suggest that primary afferent depolarization of the central fibers of one CSN by stimulation of the contralateral CSN might be contributing to this inhibitory interaction. The data suggest that the outcome of integrative interactions between right and left CSN inputs to NTS neurons may depend largely on the temporal sequence of convergent afferent impulses.
Details
- Title: Subtitle
- Interactions in nucleus tractus solitarius between right and left carotid sinus nerves
- Creators
- Robert B Felder - Department of Internal Medicine, College of Medicine, University ofIowa, Iowa City 52242Cheryl M Heesch - Department of Internal Medicine, College of Medicine, University ofIowa, Iowa City 52242
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.253(5), pp.H1127-H1135
- DOI
- 10.1152/ajpheart.1987.253.5.H1127
- PMID
- 3688256
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 11/01/1987
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984065491502771
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