Journal article
Interactions of Chronic Stress Exposure and Stress Appraisal on Vascular Endothelial Function Among Young Adults
Journal of applied physiology (1985), Vol.138(3), pp.783-791
03/01/2025
DOI: 10.1152/japplphysiol.00457.2024
PMCID: PMC12208104
PMID: 39813018
Abstract
We investigated the associations of ongoing, chronic stress exposure and stress appraisal on vascular endothelial function (VEF) in young adults.
In 72 healthy young adults (74% female; age = 25±1 y), we assessed chronic stress exposure and appraisal with a measure that quantified chronic stress exposure and chronic stress appraisal related to 8 specific stressors over the last year. Participants completed the perceived stress scale (PSS) as a measure of global, proximal stress appraisal. VEF was assessed using the brachial artery flow mediated dilation technique. We examined relations among ongoing, chronic stress exposure and stress appraisal versus VEF adjusted for age and sex, and then assessed whether stress appraisal moderated the effect of chronic stress exposure on VEF.
Chronic stress exposure (β=-0.24,
=.045), but not chronic stress appraisal (β=0.07,
=.56) or perceived stress (β=-0.20,
=.11), was related to VEF. Perceived stress (p = .046), but not chronic stress appraisal (
=.54), moderated the association between chronic stress exposure and VEF. The effect of chronic stress exposure on VEF ceased to be significant at a PSS score of ~22. Subsequent exploratory stratified analysis indicated that those with PSS ≥22 had increased exposure to adverse childhood experiences (+1.6±0.6,
=.01), greater depressive symptoms (+10.2±2.7,
<.001), and reduced psychological resilience (-7.6±3.5,
=.036).
Chronic stress exposure significantly predicts impaired VEF among young adults. Further, this relation is influenced by proximal perceived stress, such that the association of chronic stress exposure on VEF may be obscured at high levels of proximal perceived stress.
Details
- Title: Subtitle
- Interactions of Chronic Stress Exposure and Stress Appraisal on Vascular Endothelial Function Among Young Adults
- Creators
- Alyssa S Carlson - Psychological and Brain Sciences, University of IowaLaura E Schwager - University of IowaThomas W Hart Jr - University of IowaSara J Diesel - University of IowaJordan L Harris - University of IowaMark Flores - University of IowaKylee West - University of IowaEmily B K Thomas - University of IowaNathaniel D M Jenkins - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.138(3), pp.783-791
- DOI
- 10.1152/japplphysiol.00457.2024
- PMID
- 39813018
- PMCID
- PMC12208104
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 1522-1601
- eISSN
- 1522-1601
- Publisher
- AMER PHYSIOLOGICAL SOC
- Grant note
- R49 CE003095 / NCIPC CDC HHS 24TPA1290435 / American Heart Association (AHA) 2L30HL149066 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL167788 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
- Language
- English
- Electronic publication date
- 01/15/2025
- Date published
- 03/01/2025
- Academic Unit
- Psychological and Brain Sciences; Center for Social Science Innovation; Injury Prevention Research Center; Health, Sport, and Human Physiology
- Record Identifier
- 9984773412502771
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