Journal article
Interactions of the Invasive Pathogens Salmonella typhimurium, Listeria monocytogenes, and Shigella flexneri with M Cells and Murine Peyer’s Patches
Infection and immunity, Vol.66(8), pp.3758-3766
08/1998
DOI: 10.1128/IAI.66.8.3758-3766.1998
PMCID: PMC108412
PMID: 9673259
Abstract
Invasive enteric bacteria must pass through the intestinal epithelium in order to establish infection. It is becoming clear that a common target for intestinal mucosa penetration is the specialized epithelial cell of Peyer’s patches, the M cell. In order to gain a better understanding of how bacteria interact with M cells, we have compared the interactions of
Salmonella typhimurium
,
Listeria monocytogenes
, and
Shigella flexneri
with M cells by using a murine ligated-loop model. Our results indicate that
S. typhimurium
possesses a highly efficient mechanism for M cell entry that targets and destroys these cells, while
L. monocytogenes
and
S. flexneri
appear to be internalized into M cells in a less disruptive fashion. Early uptake of
Listeria
or
Shigella
into M cells appeared to lead to the death of some cells, as evidenced by the appearance of holes in the intestinal epithelium. At later time points, the follicle-associated epithelium of animals infected with these bacteria displayed extensive destruction. These data indicate that enteric pathogens use different strategies to interact with M cells and initiate infection of a host.
Details
- Title: Subtitle
- Interactions of the Invasive Pathogens Salmonella typhimurium, Listeria monocytogenes, and Shigella flexneri with M Cells and Murine Peyer’s Patches
- Creators
- V. Behrana Jensen - Department of Microbiology, University of Iowa School of Medicine, Iowa City, Iowa 52242-1109John T Harty - Department of Microbiology, University of Iowa School of Medicine, Iowa City, Iowa 52242-1109Bradley D Jones - Department of Microbiology, University of Iowa School of Medicine, Iowa City, Iowa 52242-1109
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.66(8), pp.3758-3766
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/IAI.66.8.3758-3766.1998
- PMID
- 9673259
- PMCID
- PMC108412
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Language
- English
- Date published
- 08/1998
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984046915402771
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