Journal article
Interactive Contributions of Intracellular Calcium and Protein Phosphatases to Massed-Trials Learning Deficits in Hermissenda
Behavioral neuroscience, Vol.113(1), pp.103-117
02/1999
DOI: 10.1037/0735-7044.113.1.103
PMID: 10197910
Abstract
Using
Hermissenda
as subjects, massed-trials training deficits were examined. Associative pairings
of light and rotation induced a progressively greater conditioned
foot contraction in response to light as the intertrial interval
(ITI) was extended (up to 8 min). In contrast, a short ITI (30 s)
produced no evidence of learning. In a corresponding in vitro
conditioning experiment that mimicked training of the intact animal, facilitation of neuronal excitability in the animal's B
photoreceptors paralleled the results obtained in vivo. Imaging of
intracellular Ca
2+
using Fura-2
indicated that Ca
2+
levels remained
elevated during short ITIs. This Ca
2+
accumulation appears to induce activation of protein phosphatases
because normal facilitation of the B photoreceptors was induced with
a short ITI if training occurred in the presence of a phosphatase
inhibitor. These results suggest that intracellular Ca
2+
and protein phosphatases
contribute interactively to the kinetics of memory formation and
provide evidence that an accumulation of intracellular Ca
2+
across training trials may impede
memory formation.
Details
- Title: Subtitle
- Interactive Contributions of Intracellular Calcium and Protein Phosphatases to Massed-Trials Learning Deficits in Hermissenda
- Creators
- Isabel A Muzzio - Rutgers, The State University of New JerseyRey R Ramirez - Department of Psychology, Program in Biopsychology and Behavioral Neuroscience, Rutgers, The State University of New JerseyAndrew C Talk - Rutgers, The State University of New JerseyLouis D Matzel - Rutgers, The State University of New Jersey
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.113(1), pp.103-117
- DOI
- 10.1037/0735-7044.113.1.103
- PMID
- 10197910
- NLM abbreviation
- Behav Neurosci
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Publisher
- American Psychological Association
- Language
- English
- Date published
- 02/1999
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984294923102771
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