Journal article
Interactive Effects of Naturalistic Drinking Context and Alcohol Sensitivity on Neural Alcohol Cue-Reactivity Responses
Alcoholism, clinical and experimental research, Vol.43(8), pp.1777-1789
08/2019
DOI: 10.1111/acer.14134
PMCID: 6677613
PMID: 31233217
Abstract
Background Considerable evidence indicates that a low level of subjective response to alcohol's acute effects (i.e., low sensitivity) is associated with enhanced risk for alcohol use disorder (AUD). Recent work suggests that the highest risk response profile consists of blunted sensitivity to alcohol's sedation-like effects, coupled with enhanced sensitivity to alcohol's stimulation-like effects (i.e., differential sensitivity). A largely separate body of work indicates that enhanced reactivity to alcohol-related cues is associated with increased AUD risk. Aims The current research examined the extent to which variability in alcohol response phenotypes is associated with enhanced P3 event-related potential (ERP) responses to alcohol-related pictures (ACR-P3), and whether this reactivity varies according to depicted drinking contexts. Methods Eighty young adults (aged 18 to 33 years) completed a self-report measure of alcohol sensitivity (the Alcohol Sensitivity Questionnaire) and viewed images depicting drinking in naturalistic contexts, alcohol and nonalcohol beverages in isolation (devoid of naturalistic drinking context), and neutral nonbeverage control images while ERPs were recorded. Results Results indicated that blunted sensitivity to alcohol's sedative-like effects was differentially associated with enhanced ACR-P3 but reduced P3 reactivity to nonalcohol cues. Variation in sensitivity to alcohol's stimulant-like effects was not associated with differential ACR-P3. Contrary to predictions, these effects were not potentiated by drinking contexts. Conclusions The current results replicate and extend previous work linking low alcohol sensitivity with enhanced incentive salience for alcohol-related cues and suggest that cues depicting drinking contexts are less likely to differentiate high-risk from low-risk drinkers.
Details
- Title: Subtitle
- Interactive Effects of Naturalistic Drinking Context and Alcohol Sensitivity on Neural Alcohol Cue-Reactivity Responses
- Creators
- Jorge S. Martins - University of MissouriBruce D. Bartholow - University of MissouriM. Lynne Cooper - University of MissouriKelsey M. Irvin - University of MissouriThomas M. Piasecki - University of Missouri
- Resource Type
- Journal article
- Publication Details
- Alcoholism, clinical and experimental research, Vol.43(8), pp.1777-1789
- DOI
- 10.1111/acer.14134
- PMID
- 31233217
- PMCID
- 6677613
- NLM abbreviation
- Alcohol Clin Exp Res
- ISSN
- 0145-6008
- eISSN
- 1530-0277
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- SFRH/BD/9261/2013 / Fundacao para a Ciencia e a Tecnologia, IP (FCT); Fundacao para a Ciencia e a Tecnologia (FCT) R01 AA025451 / National Institute on Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) POPH/FSE funding program of the Portuguese government
- Language
- English
- Date published
- 08/2019
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984446397502771
Metrics
4 Record Views