Journal article
Intercellular adhesion molecule 1 and progression of percent emphysema: The MESA Lung Study
Respiratory medicine, Vol.109(2), pp.255-264
02/2015
DOI: 10.1016/j.rmed.2014.10.004
PMCID: PMC4331236
PMID: 25457724
Abstract
Endothelial intercellular adhesion molecule (ICAM) 1 binds neutrophils and facilitates their transmigration into the lung; E-selectin facilitates leukocyte rolling. As neutrophils contribute to tissue destruction in emphysema and chronic obstructive pulmonary disease, we hypothesized that soluble ICAM-1 (sICAM-1) and E-selectin (sE-selectin) would be associated with longitudinal progression of emphysema and lung function decline.
The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45–84 years old without clinical cardiovascular disease in 2000–02. The MESA Lung Study assessed percent emphysema (<−950 Hounsfield units) on cardiac (2000–07) and full-lung CT scans (2010–12), and spirometry was assessed twice over five years. sICAM-1 and sE-selectin were measured at baseline. Mixed-effect models adjusted for demographics, anthropometry, smoking, C-reactive protein, sphingomyelin and scanner factors.
Among 1865 MESA Lung participants with measurement of sICAM-1 and percent emphysema the mean log-sICAM-1 was 5.5 ± 0.3 ng/mL and percent emphysema increased 0.73 percentage points (95% CI: 0.34, 1.12; P < 0.001) over ten years. A one SD increase in sICAM-1 was associated with an accelerated increase in percent emphysema of 0.23 percentage points over ten years (95% CI: 0.06, 0.39; P = 0.007). No significant association was found for sE-selectin, or between any adhesion molecule and lung function.
Higher levels of sICAM-1 were independently associated with progression of percent emphysema in a general population sample.
Details
- Title: Subtitle
- Intercellular adhesion molecule 1 and progression of percent emphysema: The MESA Lung Study
- Creators
- Carrie P Aaron - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USAJoseph E Schwartz - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USASuzette J Bielinski - Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USAEric A Hoffman - Department of Radiology, University of Iowa, Iowa City, IA, USAJohn H.M Austin - Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY, USAElizabeth C Oelsner - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USAKathleen M Donohue - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USARavi Kalhan - Department of Medicine, Northwestern University, Chicago, IL, USACecilia Berardi - Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USAJoel D Kaufman - Department of Environmental Medicine and Occupational Health Sciences, University of Washington, Seattle, WA, USADavid R Jacobs - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USARussell P Tracy - Department of Pathology, University of Vermont, Colchester, VT, USAR. Graham Barr - Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
- Resource Type
- Journal article
- Publication Details
- Respiratory medicine, Vol.109(2), pp.255-264
- DOI
- 10.1016/j.rmed.2014.10.004
- PMID
- 25457724
- PMCID
- PMC4331236
- NLM abbreviation
- Respir Med
- ISSN
- 0954-6111
- eISSN
- 1532-3064
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: N01-HC-95159, N01-HC-95169; DOI: 10.13039/100000097, name: National Center for Research Resources, award: UL1-RR-024156, UL1-RR-025005
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051744702771
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