Intercepting Modes of Cellular Communication

Kristin E. Claflin; Matthew J. Potthoff

doi:10.1016/j.jcmgh.2025.101531

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Intercepting Modes of Cellular Communication

Journal article

Open access

Peer reviewed

Intercepting Modes of Cellular Communication

Kristin E. Claflin and Matthew J. Potthoff

Cellular and molecular gastroenterology and hepatology, Vol.19(8), 101531

2025

DOI: 10.1016/j.jcmgh.2025.101531

PMCID: PMC12209953

PMID: 40348018

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Abstract

Metabolic homeostasis is maintained through a delicate balance of communication within and between multiple organ systems. These communication networks are essential for regulating nutrient intake, utilization, and storage. Conditions of metabolic dysfunction can impair proper tissue communication, which contributes to the progression of metabolic disease including obesity, hepatic steatosis, and type II diabetes. In this collection of Cellular and Molecular Gastroenterology and Hepatology, we highlight new advances in transcellular and interorgan communication, particularly in the liver and gastrointestinal (GI) tract, and how impairments in these biologic networks contribute to metabolic disease. In addition, we emphasize the therapeutic potential for modulating these communication pathways to treat metabolic disease.

Liver

Hepatokines

Communication

Metabolism

MASH

Gut

Details

Title: Subtitle: Intercepting Modes of Cellular Communication
Creators: Kristin E. Claflin - University of Iowa
Matthew J. Potthoff - Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
Resource Type: Journal article
Publication Details: Cellular and molecular gastroenterology and hepatology, Vol.19(8), 101531
DOI: 10.1016/j.jcmgh.2025.101531
PMID: 40348018
PMCID: PMC12209953
NLM abbreviation: Cell Mol Gastroenterol Hepatol
ISSN: 2352-345X
eISSN: 2352-345X
Publisher: Elsevier Inc
Grant note: National Institutes of Health: R01DK106104, R01AA027654, K01DK133667 Veterans Affairs Merit Review Program: I01BX004634
Funding This work was funded by the National Institutes of Health R01DK106104 (Matthew J. Potthoff) , R01AA027654 (Matthew J. Potthoff) , and K01DK133667 (Kristin E. Claflin) , and Veterans Affairs Merit Review Program I01BX004634 (Matthew J. Potthoff) .
Language: English
Electronic publication date: 05/08/2025
Date published: 2025
Academic Unit: Neuroscience and Pharmacology
Record Identifier: 9984822964902771

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