Journal article
Interference Competition Among Natural Fungal Competitors: an Antifungal Metabolite from the Coprophilous Fungus Preussia fleischhakii
Journal of natural products (Washington, D.C.), Vol.51(5), pp.879-883
09/01/1988
DOI: 10.1021/np50059a011
PMID: 21401198
Abstract
Compound 1 (2,3'-dihydroxy-4-methoxy-5',6-dimethyldiphenyl ether) has been established as the major causative agent of interference competition between Preussia fleischhakii, a fungal colonist of rabbit dung, and two early successional dung colonists, Ascobolus furfuraceus and Sordaria fimicola. Compound 1 was isolated from EtOAc extracts of liquid cultures of P. fleischhakii by Si gel chromatography and reversed-phase hplc and was identified by analysis of 1H-nmr, 13C-nmr, and ms data. The isolation process was guided by in vitro bioassays for antifungal activity against A. furfuraceus and S. fimicola. These results suggest that studies of interference competition observed in relatively unexplored natural fungal communities may be a valuable, ecologically rational approach to the discovery of antifungal agents. © 1988, American Chemical Society. All rights reserved.
Details
- Title: Subtitle
- Interference Competition Among Natural Fungal Competitors: an Antifungal Metabolite from the Coprophilous Fungus Preussia fleischhakii
- Creators
- Holly A WeberJames B Gloer
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.51(5), pp.879-883
- Publisher
- American Chemical Society
- DOI
- 10.1021/np50059a011
- PMID
- 21401198
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Language
- English
- Date published
- 09/01/1988
- Academic Unit
- Chemistry
- Record Identifier
- 9984216562302771
Metrics
10 Record Views