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Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate
Journal article   Peer reviewed

Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate

Theresa M Zucchero, Margaret E. Cooper, Brion S Maher, Sandra Daack-Hirsch, Buena Nepomuceno, Lucilene Ribeiro, Diana Caprau, Kaare Christensen, Yasushi Suzuki, Junichiro Machida, …
The New England journal of medicine, Vol.351(8), pp.769-780
08/19/2004
DOI: 10.1056/NEJMoa032909
PMID: 15317890

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Abstract

<p>BACKGROUND: Cleft lip or palate (or the two in combination) is a common birth defect that results from a mixture of genetic and environmental factors. We searched for a specific genetic factor contributing to this complex trait by examining large numbers of affected patients and families and evaluating a specific candidate gene. METHODS: We identified the gene that encodes interferon regulatory factor 6 (IRF6) as a candidate gene on the basis of its involvement in an autosomal dominant form of cleft lip and palate, Van der Woude's syndrome. A single-nucleotide polymorphism in this gene results in either a valine or an isoleucine at amino acid position 274 (V274I). We carried out transmission-disequilibrium testing for V274I in 8003 individual subjects in 1968 families derived from 10 populations with ancestry in Asia, Europe, and South America, haplotype and linkage analyses, and case-control analyses, and determined the risk of cleft lip or palate that is associated with genetic variation in IRF6. RESULTS: Strong evidence of overtransmission of the valine (V) allele was found in the entire population data set (P<10(-9)); moreover, the results for some individual populations from South America and Asia were highly significant. Variation at IRF6 was responsible for 12 percent of the genetic contribution to cleft lip or palate and tripled the risk of recurrence in families that had already had one affected child. CONCLUSIONS: DNA-sequence variants associated with IRF6 are major contributors to cleft lip, with or without cleft palate. The contribution of variants in single genes to cleft lip or palate is an important consideration in genetic counseling.</p>
 Nursing Cleft Lip/genetics Cleft Palate/genetics Continental Population Groups DNA-Binding Proteins/genetics Genotype Haplotypes Humans Interferon Regulatory Factors Linkage Disequilibrium Pedigree Polymorphism Genetic Risk Factors Transcription Factors/genetics Valine

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