Interferon α activates the tyrosine kinase Lyn in haemopoietic cells

Shahab Uddin; Isabella M Grumbach; Taolin YI; Oscar R Colamonici; Leonidas C Platanias

doi:10.1046/j.1365-2141.1998.00731.x

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Interferon α activates the tyrosine kinase Lyn in haemopoietic cells

Journal article

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Interferon α activates the tyrosine kinase Lyn in haemopoietic cells

Shahab Uddin, Isabella M Grumbach, Taolin YI, Oscar R Colamonici and Leonidas C Platanias

British journal of haematology, Vol.101(3), pp.446-449

06/1998

DOI: 10.1046/j.1365-2141.1998.00731.x

PMID: 9633884

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Abstract

We investigated whether the src-family tyrosine kinase Lyn is involved in the generation of interferon alpha (IFN alpha) signals in haemopoietic cells. In vitro kinase assays using IFN alpha-sensitive cells of B-cell origin demonstrated the presence of IFN alpha-dependent kinase activity in anti-Lyn immunoprecipitates. Further studies demonstrated that Lyn associates via its src homology 2 (SH2) domain with the Janus family tyrosine kinase Tyk-2. This interaction was IFN alpha-dependent and involved direct binding of the SH2 domain of Lyn to the IFN alpha-activated form of Tyk-2. Thus, during binding of IFN alpha to its receptor in malignant haemopoietic cells, Lyn is engaged in an IFN alpha-signalling pathway, probably downstream of Tyk-2.

Details

Title: Subtitle: Interferon α activates the tyrosine kinase Lyn in haemopoietic cells
Creators: Shahab Uddin - Section of Hematology‐Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Affairs Hospital, Chicago, Illinois, U.S.A
Isabella M Grumbach - Section of Hematology‐Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Affairs Hospital, Chicago, Illinois, U.S.A
Taolin YI - Department of Cancer Biology, The Cleveland Clinic Foundation Research Institute, Cleveland, Ohio, U.S.A
Oscar R Colamonici - Department of Pathology, University of Tennessee, Memphis, Tennessee, U.S.A
Leonidas C Platanias - Section of Hematology‐Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Affairs Hospital, Chicago, Illinois, U.S.A
Resource Type: Journal article
Publication Details: British journal of haematology, Vol.101(3), pp.446-449
DOI: 10.1046/j.1365-2141.1998.00731.x
PMID: 9633884
ISSN: 0007-1048
eISSN: 1365-2141
Language: English
Date published: 06/1998
Academic Unit: Cardiovascular Medicine; Radiation Oncology; Internal Medicine
Record Identifier: 9984094874502771

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