Interim Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalization Among Immunocompetent Adults Aged ≥18 Years - VISION and IVY Networks, September 2023-January 2024

Jennifer DeCuir; Amanda B Payne; Wesley H Self; Elizabeth A K Rowley; Kristin Dascomb; Malini B DeSilva; Stephanie A Irving; Shaun J Grannis; Toan C Ong; Nicola P Klein; Zachary A Weber; Sarah E Reese; Sarah W Ball; Michelle A Barron; Allison L Naleway; Brian E Dixon; Inih Essien; Daniel Bride; Karthik Natarajan; Bruce Fireman; Ami B Shah; Erica Okwuazi; Ryan Wiegand; Yuwei Zhu; Adam S Lauring; Emily T Martin; Manjusha Gaglani; Ithan D Peltan; Samuel M Brown; Adit A Ginde; Nicholas M Mohr; Kevin W Gibbs; David N Hager; Matthew Prekker; Amira Mohamed; Vasisht Srinivasan; Jay S Steingrub; Akram Khan; Laurence W Busse; Abhijit Duggal; Jennifer G Wilson; Steven Y Chang; Christopher Mallow; Jennie H Kwon; Matthew C Exline; Cristie Columbus; Ivana A Vaughn; Basmah Safdar; Jarrod M Mosier; Estelle S Harris; Jonathan D Casey; James D Chappell; Carlos G Grijalva; Sydney A Swan; Cassandra Johnson; Nathaniel M Lewis; Sascha Ellington; Katherine Adams; Mark W Tenforde; Clinton R Paden; Fatimah S Dawood; Katherine E Fleming-Dutra; Diya Surie; Ruth Link-Gelles; CDC COVID-19 Vaccine Effectiveness Collaborators

doi:10.15585/mmwr.mm7308a5

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Interim Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalization Among Immunocompetent Adults Aged ≥18 Years - VISION and IVY Networks, September 2023-January 2024

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Interim Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalization Among Immunocompetent Adults Aged ≥18 Years - VISION and IVY Networks, September 2023-January 2024

Jennifer DeCuir, Amanda B Payne, Wesley H Self, Elizabeth A K Rowley, Kristin Dascomb, Malini B DeSilva, Stephanie A Irving, Shaun J Grannis, Toan C Ong, Nicola P Klein, …

MMWR. Morbidity and mortality weekly report, Vol.73(8), pp.180-188

02/29/2024

DOI: 10.15585/mmwr.mm7308a5

PMCID: PMC10907041

PMID: 38421945

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Abstract

In September 2023, CDC's Advisory Committee on Immunization Practices recommended updated 2023-2024 (monovalent XBB.1.5) COVID-19 vaccination for all persons aged ≥6 months to prevent COVID-19, including severe disease. However, few estimates of updated vaccine effectiveness (VE) against medically attended illness are available. This analysis evaluated VE of an updated COVID-19 vaccine dose against COVID-19-associated emergency department (ED) or urgent care (UC) encounters and hospitalization among immunocompetent adults aged ≥18 years during September 2023-January 2024 using a test-negative, case-control design with data from two CDC VE networks. VE against COVID-19-associated ED/UC encounters was 51% (95% CI = 47%-54%) during the first 7-59 days after an updated dose and 39% (95% CI = 33%-45%) during the 60-119 days after an updated dose. VE estimates against COVID-19-associated hospitalization from two CDC VE networks were 52% (95% CI = 47%-57%) and 43% (95% CI = 27%-56%), with a median interval from updated dose of 42 and 47 days, respectively. Updated COVID-19 vaccine provided increased protection against COVID-19-associated ED/UC encounters and hospitalization among immunocompetent adults. These results support CDC recommendations for updated 2023-2024 COVID-19 vaccination. All persons aged ≥6 months should receive updated 2023-2024 COVID-19 vaccine.

Details

Title: Subtitle: Interim Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalization Among Immunocompetent Adults Aged ≥18 Years - VISION and IVY Networks, September 2023-January 2024
Creators: Jennifer DeCuir
Amanda B Payne
Wesley H Self
Elizabeth A K Rowley
Kristin Dascomb
Malini B DeSilva
Stephanie A Irving
Shaun J Grannis
Toan C Ong
Nicola P Klein
Zachary A Weber
Sarah E Reese
Sarah W Ball
Michelle A Barron
Allison L Naleway
Brian E Dixon
Inih Essien
Daniel Bride
Karthik Natarajan
Bruce Fireman
Ami B Shah
Erica Okwuazi
Ryan Wiegand
Yuwei Zhu
Adam S Lauring
Emily T Martin
Manjusha Gaglani
Ithan D Peltan
Samuel M Brown
Adit A Ginde
Nicholas M Mohr
Kevin W Gibbs
David N Hager
Matthew Prekker
Amira Mohamed
Vasisht Srinivasan
Jay S Steingrub
Akram Khan
Laurence W Busse
Abhijit Duggal
Jennifer G Wilson
Steven Y Chang
Christopher Mallow
Jennie H Kwon
Matthew C Exline
Cristie Columbus
Ivana A Vaughn
Basmah Safdar
Jarrod M Mosier
Estelle S Harris
Jonathan D Casey
James D Chappell
Carlos G Grijalva
Sydney A Swan
Cassandra Johnson
Nathaniel M Lewis
Sascha Ellington
Katherine Adams
Mark W Tenforde
Clinton R Paden
Fatimah S Dawood
Katherine E Fleming-Dutra
Diya Surie
Ruth Link-Gelles
CDC COVID-19 Vaccine Effectiveness Collaborators
Resource Type: Journal article
Publication Details: MMWR. Morbidity and mortality weekly report, Vol.73(8), pp.180-188
DOI: 10.15585/mmwr.mm7308a5
PMID: 38421945
PMCID: PMC10907041
NLM abbreviation: MMWR Morb Mortal Wkly Rep
eISSN: 1545-861X
Language: English
Date published: 02/29/2024
Academic Unit: Epidemiology; Emergency Medicine; Anesthesia; Injury Prevention Research Center
Record Identifier: 9984563556502771

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