Journal article
Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna COVID-19 Vaccines Among Health Care Personnel-33 US Sites, January-March 2021
MMWR. Morbidity and mortality weekly report, Vol.70(20), pp.753-758
05/21/2021
DOI: 10.15585/mmwr.mm7020e2
PMCID: PMC8136422
PMID: 34014909
Abstract
Throughout the COVID-19 pandemic, health care personnel (HCP) have been at high risk for exposure to SARS-CoV-2, the virus that causes COVID-19, through patient interactions and community exposure (1). The Advisory Committee on Immunization Practices recommended prioritization of HCP for COVID-19 vaccination to maintain provision of critical services and reduce spread of infection in health care settings (2). Early distribution of two mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna) to HCP allowed assessment of the effectiveness of these vaccines in a real-world setting. A test-negative case-control study is underway to evaluate mRNA COVID-19 vaccine effectiveness (VE) against symptomatic illness among HCP at 33 U.S. sites across 25 U.S. states. Interim analyses indicated that the VE of a single dose (measured 14 days after the first dose through 6 days after the second dose) was 82% (95% confidence interval [CI] = 74%-87%), adjusted for age, race/ethnicity, and underlying medical conditions. The adjusted VE of 2 doses (measured ≥7 days after the second dose) was 94% (95% CI = 87%-97%). VE of partial (1-dose) and complete (2-dose) vaccination in this population is comparable to that reported from clinical trials and recent observational studies, supporting the effectiveness of mRNA COVID-19 vaccines against symptomatic disease in adults, with strong 2-dose protection.
Details
- Title: Subtitle
- Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna COVID-19 Vaccines Among Health Care Personnel-33 US Sites, January-March 2021
- Creators
- Tamara Pilishvili - Centers for Disease Control and PreventionKatherine E. Fleming-Dutra - Centers for Disease Control and PreventionJennifer L. Farrar - Centers for Disease Control and PreventionRyan Gierke - Centers for Disease Control and PreventionNicholas M. Mohr - University of IowaDavid A. Talan - Los Angeles Medical CenterAnusha Krishnadasan - Los Angeles Medical CenterKarisa K. Harland - University of IowaHoward A. Smithline - Tufts UniversityPeter C. Hou - Harvard UniversityLilly C. Lee - Jackson Memorial HospitalStephen C. Lim - Louisiana State UniversityGregory J. Moran - Los Angeles Medical CenterElizabeth Krebs - Thomas Jefferson UniversityMark Steele - Truman Medical CenterDavid G. Beiser - University of ChicagoBrett Faine - University of IowaJohn P. Haran - University of Massachusetts Chan Medical SchoolUtsav Nandi - University of MississippiWalter A. Schrading - University of Alabama at BirminghamBrian Chinnock - University of California, San FranciscoDaniel J. Henning - University of WashingtonFrank LoVecchio - Valley Medical CenterJoelle Nadle - California Emerging Infections ProgramDevra Barter - Colorado Department of Public Health and EnvironmentMonica Brackney - Yale UniversityAmber Britton - Emory UniversityKaytlynn Marceaux-Galli - Maryland Department of HealthSarah Lim - Minnesota Department of HealthErin C. Phipps - University of New MexicoGhinwa Dumyati - University of RochesterRebecca Pierce - Oregon Health AuthorityTiffanie M. Markus - Vanderbilt UniversityDeverick J. Anderson - Duke UniversityAmanda K. Debes - Johns Hopkins UniversityMichael Lin - Rush UniversityJeanmarie Mayer - University of UtahHilary M. Babcock - Washington University in St. Louis School of MedicineNasia Safdar - University of Wisconsin–MadisonRosalyn Singleton - Alaska Native Tribal Health ConsortiumMarc Fischer - Centers for Disease Control and PreventionNora Chea - Centers for Disease Control and PreventionShelley S. Magill - Centers for Disease Control and PreventionJennifer Verani - Centers for Disease Control and PreventionStephanie Schrag - Centers for Disease Control and PreventionVaccine Effectiveness Among Healthcare Personnel Study Team
- Resource Type
- Journal article
- Publication Details
- MMWR. Morbidity and mortality weekly report, Vol.70(20), pp.753-758
- DOI
- 10.15585/mmwr.mm7020e2
- PMID
- 34014909
- PMCID
- PMC8136422
- NLM abbreviation
- MMWR Morb Mortal Wkly Rep
- ISSN
- 0149-2195
- eISSN
- 1545-861X
- Publisher
- Centers Disease Control & Prevention
- Number of pages
- 6
- Language
- English
- Date published
- 05/21/2021
- Academic Unit
- Epidemiology; Emergency Medicine; Pharmacy Practice and Science; Anesthesia; Injury Prevention Research Center; Law Faculty; Internal Medicine
- Record Identifier
- 9984296138502771
Metrics
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