Journal article
Interleukin-1β is associated with coronary endothelial dysfunction in patients with mTOR-inhibitor-eluting stent implantation
Heart and vessels, Vol.32(7), pp.823-832
07/01/2017
DOI: 10.1007/s00380-017-0947-x
PMID: 28116487
Abstract
Implantation of mammalian target of rapamycin (mTOR)-inhibitor drug-eluting stents (DESs) impairs coronary endothelial function. There are no known non-invasive biomarkers of coronary endothelial dysfunction. We aimed to assess the association between serum interleukin-1beta (IL-1β) and coronary endothelial dysfunction in patients with mTOR-inhibitor DES implantation and to investigate the association between the mTOR pathway and IL-1β. We enrolled 35 patients who had implanted DESs for coronary artery disease. At a 10-month follow-up, peripheral venous blood samples were collected to measure IL-1β levels. Coronary endothelial dysfunction was evaluated by intracoronary infusion of incremental doses of acetylcholine. Serum IL-1β levels were significantly associated with the magnitude of vasoconstriction to acetylcholine at the segment distal (P < 0.05) but not proximal to the stent. Serum IL-1β levels were positively correlated with stent length (P < 0.05). To examine the direct effects of mTOR inhibition on IL-1β release, sirolimus was incubated in cultured human umbilical vein endothelial cells (HUVECs) or coronary artery smooth muscle cells (CASMCs). Sirolimus directly increased IL-1β mRNA expression (P < 0.01) and enhanced IL-1β release into the culture media (P < 0.01) in CASMCs, but not in HUVECs. Inhibition of mTOR triggers IL-1β release through transcriptional activation in CASMCs. Serum IL-1β levels are a potential biomarker for mTOR-inhibitor DES-associated coronary endothelial dysfunction.
Details
- Title: Subtitle
- Interleukin-1β is associated with coronary endothelial dysfunction in patients with mTOR-inhibitor-eluting stent implantation
- Creators
- Hidetoshi Chibana - Kurume UniversityHidemi Kajimoto - Kurume UniversityTakafumi Ueno - Kurume UniversityShinji Yokoyama - Kurume UniversityKen-Ichiro Sasaki - Kurume UniversityMasanori Ohtsuka - Kurume UniversityHiroshi Koiwaya - Kurume UniversityTakaharu Nakayoshi - Kurume UniversityYoshiaki Mitsutake - Kurume UniversityNaoki Itaya - Kurume UniversityMasahiro Sasaki - Kurume UniversityYoshihiro Fukumoto - Kurume University
- Resource Type
- Journal article
- Publication Details
- Heart and vessels, Vol.32(7), pp.823-832
- DOI
- 10.1007/s00380-017-0947-x
- PMID
- 28116487
- NLM abbreviation
- Heart Vessels
- ISSN
- 0910-8327
- eISSN
- 1615-2573
- Language
- English
- Date published
- 07/01/2017
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984961027702771
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