Journal article
Interleukin-2 receptor antagonist immunosuppression and consecutive viral management in living-donor liver transplantation for human immunodeficiency virus/hepatitis C-co-infected patients: a report of 2 cases
Clinical journal of gastroenterology, Vol.9(1), pp.32-37
02/2016
DOI: 10.1007/s12328-015-0621-8
PMID: 26661842
Abstract
Management of immunosuppression for human immunodeficiency virus/hepatitis C (HIV/HCV) in living-donor liver transplantation (LDLT) has not been established. We performed LDLT for two patients with HIV/HCV-co-infected end-stage liver disease. The immunosuppression protocol consisted of early calcineurin inhibitor-free and interleukin-2 receptor antagonist (IL2Ra) induction and methylprednisolone. Maintenance low-dose tacrolimus was started and anti-retroviral therapy for HIV was re-started 1 week after LDLT. Consecutively, pegylated interferon and ribavirin therapy were successfully added as pre-emptive therapy for HCV. HIV-RNA and HCV-RNA were undetectable on anti-retroviral therapy and HCV treatment at 17 and 8 months after LDLT, respectively, with normal liver function. This study is the first report of early calcineurin inhibitor-free and IL2Ra induction with methylprednisolone immunosuppression in LDLT for HIV/HCV-co-infected patients with a favorable outcome. Consecutive HIV/HCV treatment was well tolerated.
Details
- Title: Subtitle
- Interleukin-2 receptor antagonist immunosuppression and consecutive viral management in living-donor liver transplantation for human immunodeficiency virus/hepatitis C-co-infected patients: a report of 2 cases
- Creators
- Harufumi Maki - Hepato-Biliary-Pancreatic Surgery Division, and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo JapanJunichi Kaneko - Hepato-Biliary-Pancreatic Surgery Division, and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo JapanNobuhisa Akamatsu - Hepato-Biliary-Pancreatic Surgery Division, and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo JapanJunichi Arita - Hepato-Biliary-Pancreatic Surgery Division, and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo JapanYoshihiro Sakamoto - Hepato-Biliary-Pancreatic Surgery Division, and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo JapanKiyoshi Hasegawa - Hepato-Biliary-Pancreatic Surgery Division, and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo JapanTomohiro Tanaka - Organ Transplantation Service The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanSumihito Tamura - Hepato-Biliary-Pancreatic Surgery Division, and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo JapanYasuhiko Sugawara - Hepato-Biliary-Pancreatic Surgery Division, and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo JapanKunihisa Tsukada - AIDS Clinical Center National Center for Global Health and Medicine Tokyo JapanNorihiro Kokudo - Hepato-Biliary-Pancreatic Surgery Division, and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine The University of Tokyo Tokyo Japan
- Resource Type
- Journal article
- Publication Details
- Clinical journal of gastroenterology, Vol.9(1), pp.32-37
- Publisher
- Springer Japan
- DOI
- 10.1007/s12328-015-0621-8
- PMID
- 26661842
- ISSN
- 1865-7257
- eISSN
- 1865-7265
- Grant note
- 26462039 / Ministry of Education, Culture, Sports, Science, and Technology of Japan Eguchi project / Ministry of Health, Labour and Welfare (http://dx.doi.org/10.13039/501100003478)
- Language
- English
- Date published
- 02/2016
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094360502771
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