Journal article
Interleukin-2 receptor antagonist immunosuppression in liver transplantation for human immunodeficiency virus / hepatitis C coinfected end-stage liver disease patients―A report of 3 cases
Ishoku, Vol.51(2-3), pp.211-217
06/10/2016
DOI: 10.11386/jst.51.2-3_211
Abstract
A conclusion that immunosuppression and postoperative human immunodeficiency virus / hepatitis C (HIV/HCV) coinfected patient management for a liver transplantation has not been established. We performed 2 living donor and 1 deceased donor liver transplantations for patients with HIV/HCV coinfected end-stage liver disease. The immunosuppression protocol consisted of early calcineurin inhibitor-free and interleukin-2 receptor antagonist induction and methylprednisolone. Maintenance low-dose tacrolimus was started, and antiretroviral therapy for HIV was restarted 1 week after liver transplantation. Consecutively, anti-HCV therapy was added. Median 15 months later, HIV-RNA and HCV-RNA of all patients were undetectable on antiretroviral therapy and anti-HCV treatment with no drug-to-drug interactions. Interleukin-2 receptor antagonist induction with methylprednisolone immunosuppression in HIV/HCV coinfected patients was favorable.
Details
- Title: Subtitle
- Interleukin-2 receptor antagonist immunosuppression in liver transplantation for human immunodeficiency virus / hepatitis C coinfected end-stage liver disease patients―A report of 3 cases
- Creators
- Harufumi Maki - The University of TokyoJunichi Kaneko - The University of TokyoNobuhisa Akamatsu - The University of TokyoJunichi Arita - The University of TokyoYoshihiro Sakamoto - The University of TokyoSumihito Tamura - The University of TokyoKiyoshi Hasegawa - The University of TokyoYasuhiko Sugawara - The University of TokyoTomohiro Tanaka - The University of TokyoKayo Nojiri - The University of TokyoKunihisa Tsukada - AIDS Clinical Center, National Center for Global Health and MedicineMitsuhisa Takatsuki - Nagasaki UniversityMasaaki Hidaka - Nagasaki UniversityAkihiko Soyama - Nagasaki UniversityKoji Natsuda - Nagasaki UniversitySusumu Eguchi - Nagasaki UniversityNorihiro Kokudo - The University of Tokyo
- Resource Type
- Journal article
- Publication Details
- Ishoku, Vol.51(2-3), pp.211-217
- Publisher
- The Japan Society for Transplantation
- DOI
- 10.11386/jst.51.2-3_211
- ISSN
- 0578-7947
- eISSN
- 2188-0034
- Language
- Japanese
- Date published
- 06/10/2016
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984363452202771
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