Interleukin 6 Receptor Blockade for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Andreu Vilaseca; Philippe A. Bilodeau; Georgios Gakis; Andrea Savransky; Joao Mahler Ferreira Oliveira; Linda Nguyen; Sam I. Hooshmand; Sammita Satyanarayan; Carson E. Moseley; Leah Haley; Chantal Roy-Hewitson; Mariano Marrodan; Adriana Casallas; Analisa Manin; Haiwen Chen; Yoji Hoshina; Aniela Grzezulkowska; Edgar Carnero Contentti; Lorna Galleguillos; Margaret Upchurch; Caitlin S. Jackson-Tarlton; Joanne Chu-Yueh Guo; Michelle Fabian; Akash Virupakshaiah; Georgina Arrambide; César Caparó-Zamalloa; Rafael Paterno; Emmanuelle Waubant; Laura Ordoñez Boschetti; Jorge Correale; Andres M. Villa; Brenda Banwell; Romain Marignier; Sean J. Pittock; Benjamin Greenberg; Jeffrey L. Bennett; Tracey Cho; Stacey Clardy; Andrew J. Solomon; Ilya Kister; Scott S. Zamvil; Jeffrey M. Gelfand; Pavle Repovic; Ahmed Z. Obeidat; Kyle Blackburn; Silvia Tenembaum; John J. Chen; Elias S. Sotirchos; Michael Levy; Eoin P. Flanagan; Fabian Murillo; Stephanie B. Syc-Mazurzek; Laura Cacciaguerra; Mulan Jiang; Nathane Braga da Silva Rezende; Dean M Wingerchuk; Susan E. Horsman; Americas MOGAD Treatment Group

doi:10.1001/jamaneurol.2026.2220

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Interleukin 6 Receptor Blockade for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Journal article

Peer reviewed

Interleukin 6 Receptor Blockade for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Andreu Vilaseca, Philippe A. Bilodeau, Georgios Gakis, Andrea Savransky, Joao Mahler Ferreira Oliveira, Linda Nguyen, Sam I. Hooshmand, Sammita Satyanarayan, Carson E. Moseley, Leah Haley, …

JAMA neurology

07/13/2026

DOI: 10.1001/jamaneurol.2026.2220

PMID: 42440328

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Abstract

This study evaluates the impact of interleukin-6 receptor blocker therapy on relapse rates in myelin oligodendrocyte glycoprotein antibody–associated disease and compare relapse frequency with intravenous immunoglobulin.

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Title: Subtitle: Interleukin 6 Receptor Blockade for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease
Creators: Andreu Vilaseca
Philippe A. Bilodeau - Harvard University
Georgios Gakis - Johns Hopkins University
Andrea Savransky - Garrahan Hospital
Joao Mahler Ferreira Oliveira
Linda Nguyen - The University of Texas Southwestern Medical Center
Sam I. Hooshmand - Medical College of Wisconsin
Sammita Satyanarayan - Icahn School of Medicine at Mount Sinai
Carson E. Moseley - University of California, San Francisco
Leah Haley - NYU Langone Health
Chantal Roy-Hewitson - University of Vermont
Mariano Marrodan - Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
Adriana Casallas
Analisa Manin - Hospital Ramos Mejía
Haiwen Chen - Johns Hopkins University
Yoji Hoshina - University of Utah
Aniela Grzezulkowska - University of Iowa Hospitals and Clinics
Edgar Carnero Contentti
Lorna Galleguillos - Clínica Alemana
Margaret Upchurch - University of Colorado Anschutz Medical Campus
Caitlin S. Jackson-Tarlton - Dalhousie University
Joanne Chu-Yueh Guo
Michelle Fabian - Icahn School of Medicine at Mount Sinai
Akash Virupakshaiah - University of California, San Francisco
Georgina Arrambide - Vall d'Hebron Hospital Universitari
César Caparó-Zamalloa - Instituto Nacional de Enfermedades Neoplásicas
Rafael Paterno - Irmandade da Santa Casa de Misericórdia de São Paulo
Emmanuelle Waubant - University of California, San Francisco
Laura Ordoñez Boschetti
Jorge Correale - Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
Andres M. Villa - Hospital Ramos Mejía
Brenda Banwell - Johns Hopkins University
Romain Marignier - Université Claude Bernard Lyon 1
Sean J. Pittock - Mayo Clinic
Benjamin Greenberg - The University of Texas Southwestern Medical Center
Jeffrey L. Bennett - University of Colorado Anschutz Medical Campus
Tracey Cho - University of Iowa
Stacey Clardy - University of Utah
Andrew J. Solomon - University of Vermont
Ilya Kister - NYU Langone Health
Scott S. Zamvil - University of California, San Francisco
Jeffrey M. Gelfand
Pavle Repovic - Swedish Medical Center
Ahmed Z. Obeidat - Medical College of Wisconsin
Kyle Blackburn - The University of Texas Southwestern Medical Center
Silvia Tenembaum - Garrahan Hospital
John J. Chen - Mayo Clinic
Elias S. Sotirchos - Johns Hopkins University
Michael Levy - Harvard University
Eoin P. Flanagan - Mayo Clinic
Fabian Murillo - Harvard University
Stephanie B. Syc-Mazurzek - Mayo Clinic
Laura Cacciaguerra - Mayo Clinic
Mulan Jiang - Harvard University
Nathane Braga da Silva Rezende
Dean M Wingerchuk - Mayo Clinic in Arizona
Susan E. Horsman - Mayo Clinic
Americas MOGAD Treatment Group
Resource Type: Journal article
Publication Details: JAMA neurology
DOI: 10.1001/jamaneurol.2026.2220
PMID: 42440328
NLM abbreviation: JAMA Neurol
ISSN: 2168-6149
eISSN: 2168-6157
Publisher: American Medical Association
Grant note: National Institutes of Health: 1 R01 AI170863-01A1
This study was supported by the National Institutes of Health grant (R01NS113828). One patient has been included in the National Institutes of Health (1 R01 AI170863-01A1).
Alternative title: Interleukin 6 Receptor Blockade for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease
Language: English
Electronic publication date: 07/13/2026
Academic Unit: Neurology; Iowa Neuroscience Institute; Medicine Administration
Record Identifier: 9985183129602771

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