Journal article
Interleukin-6 Regulation of Direct Lung Ischemia Reperfusion Injury
The Annals of thoracic surgery, Vol.82(2), pp.472-478
2006
DOI: 10.1016/j.athoracsur.2006.03.060
PMID: 16863747
Abstract
Lung ischemia reperfusion injury continues to adversely affect patient and graft survival after transplantation. While the role of interleukin-6 has been studied in ischemia-reperfusion models of intestine, liver, and heart, its participation in lung reperfusion injury has not been characterized.
We administered recombinant interleukin-6 to rat lungs through the intratracheal route before inducing left lung ischemia and reperfusion. Multiple in-vivo indicators of left lung injury were studied, as were transactivation patterns for nuclear factor kappa B and signal transduction and activators of transcription-3. Downstream effects on the elaboration of proinflammatory chemokines and cytokines were also studied.
Recombinant interleukin-6 reduced endothelial disruption and neutrophil sequestration in left lung and alveolar spaces, resulting in improved oxygenation after ischemia and 4 hours of reperfusion. This protection was associated with decreased nuclear factor kappa B and signal transduction and activators of transcription-3 nuclear translocation early in reperfusion, and diminished proinflammatory mediator secretion late in reperfusion.
Further studies focusing on the effects of recombinant interleukin-6 in large animal models are warranted, as this may be a novel strategy to improve outcomes after lung transplantation. Intratracheal administration may focus its efficacy on the lung while reducing effects on other organ systems during organ procurement.
Details
- Title: Subtitle
- Interleukin-6 Regulation of Direct Lung Ischemia Reperfusion Injury
- Creators
- Alexander S FarivarHeather E MerryMauricio J Fica-DelgadoAnton S McCourtieBrendan C Mackinnon-PattersonMichael S Mulligan
- Resource Type
- Journal article
- Publication Details
- The Annals of thoracic surgery, Vol.82(2), pp.472-478
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.athoracsur.2006.03.060
- PMID
- 16863747
- ISSN
- 0003-4975
- eISSN
- 1552-6259
- Language
- English
- Date published
- 2006
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984040436802771
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