Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients

Susan K Lutgendorf; Aliza Z Weinrib; Frank Penedo; Daniel Russell; Koen DeGeest; Erin S Costanzo; Patrick J Henderson; Sandra E Sephton; Nicolas Rohleder; Joseph A Lucci III; Steven Cole; Anil K Sood; David M Lubaroff

doi:10.1200/JCO.2007.14.1978

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Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients

Journal article

Open access

Peer reviewed

Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients

Susan K Lutgendorf, Aliza Z Weinrib, Frank Penedo, Daniel Russell, Koen DeGeest, Erin S Costanzo, Patrick J Henderson, Sandra E Sephton, Nicolas Rohleder, Joseph A Lucci III, …

Journal of clinical oncology, Vol.26(29), pp.4820-4827

10/10/2008

DOI: 10.1200/JCO.2007.14.1978

PMCID: PMC2653140

PMID: 18779606

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Abstract

Inflammatory processes have been implicated in the pathogenesis of both depression and cancer. Links between depressive symptoms, interleukin-6 (IL-6), and cortisol dysregulation have been demonstrated in cancer patients, but vegetative versus affective components of depression have been minimally examined. The objective of the current study was to examine associations between IL-6, diurnal cortisol rhythms, and facets of depression in epithelial ovarian cancer patients. Patients awaiting surgery for a pelvic mass suspected for ovarian cancer completed questionnaires, collected salivary samples for 3 days presurgery, and gave a presurgical blood sample. Ascites was obtained during surgery. IL-6 was measured by enzyme-linked immunosorbent assay and cortisol by a chemiluminescence immunoassay. The final sample included 112 invasive ovarian cancer patients (86 advanced stage, 26 early stage) and 25 patients with tumors of low malignant potential (LMP). Advanced-stage ovarian cancer patients demonstrated elevations in vegetative and affective depressive symptoms, plasma IL-6, and the cortisol area under the curve (AUC) compared with patients with LMP tumors (all P < .05). Among invasive ovarian cancer patients, greater vegetative depression was related to elevated IL-6 in plasma (P = .008) and ascites (P = .024), but affective depression was unrelated to IL-6. Elevations in total depression (P = .026) and vegetative depression (P = .005) were also related to higher evening cortisol levels. Plasma IL-6 was related to greater afternoon and evening cortisol and cortisol AUC (all P values < .005). These results demonstrate significant relationships between IL-6, cortisol, and vegetative depression, and may have implications for treatment of depression in ovarian cancer patients.

Interleukin-6 - analysis

Humans

Middle Aged

Biomarkers - analysis

Circadian Rhythm

Neoplasms, Glandular and Epithelial - immunology

Hydrocortisone - immunology

Hydrocortisone - analysis

Interleukin-6 - immunology

Aged, 80 and over

Adult

Female

Aged

Depression - immunology

Ovarian Neoplasms - immunology

Details

Title: Subtitle: Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients
Creators: Susan K Lutgendorf - Department of Psychology, University of Iowa, Iowa City, IA 52242, USA. susan-lutgendorf@uiowa.edu
Aliza Z Weinrib
Frank Penedo
Daniel Russell
Koen DeGeest
Erin S Costanzo
Patrick J Henderson
Sandra E Sephton
Nicolas Rohleder
Joseph A Lucci III
Steven Cole
Anil K Sood
David M Lubaroff
Resource Type: Journal article
Publication Details: Journal of clinical oncology, Vol.26(29), pp.4820-4827
DOI: 10.1200/JCO.2007.14.1978
PMID: 18779606
PMCID: PMC2653140
NLM abbreviation: J Clin Oncol
ISSN: 0732-183X
eISSN: 1527-7755
Publisher: United States
Grant note: R01 CA104825 / NCI NIH HHS CA104825 / NCI NIH HHS CA88293 / NCI NIH HHS
Language: English
Date published: 10/10/2008
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984065880602771

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