Journal article
Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphatase and liver glycogen levels
The American journal of physiology, Vol.273(2), pp.E262-267
08/01/1997
DOI: 10.1152/ajpendo.1997.273.2.e262
PMID: 9277378
Abstract
Mice bearing interleukin-6 (IL-6)secreting tumor were used to study the chronic effect of IL-6 on carbohydrate metabolism. Mice were injected with allogeneic tumor cells transduced with the murine IL-6 gene. Serum IL-6 levels were correlated exponentially with tumor weight. Secretion of IL-6 from the developed tumors was associated with decreased food consumption, reduced body weight, and reduced blood glucose levels. Insulin levels did not change, and 2-deoxyglucose uptake was not affected in most tissues examined. A significant increase of 2-deoxyglucose uptake was measured in the liver. Glycogen content in the liver determined 0, 6, 12, and 18 days after tumor inoculation was 42, 23, 12, and 3 mg/g, respectively. The activity of phosphoenolpyruvate carboxykinase was not affected. The activity of glucose- 6-phosphatase (G-6-Pase) determined 6, 12, and 18 days after tumor injection was 84, 70, and 50% of G-6-Pase activity in pair-fed mice bearing nonsecreting tumors, respectively. G-6-Pase mRNA levels were markedly reduced due to inhibition of G-6-Pase gene transcriptional rate.
Details
- Title: Subtitle
- Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphatase and liver glycogen levels
- Creators
- Shula Metzger - Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.Neta Goldschmidt - Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.Varda Barash - Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.Tamar Peretz - Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.Olga DrizeJoel Shilyansky - SurgeryEitan Shiloni - National Institutes of HealthTova CHAJEK-SHAUL - Hadassah Academic College
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.273(2), pp.E262-267
- Publisher
- American Physiological Society
- DOI
- 10.1152/ajpendo.1997.273.2.e262
- PMID
- 9277378
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Language
- English
- Date published
- 08/01/1997
- Academic Unit
- Stead Family Department of Pediatrics; Surgery
- Record Identifier
- 9984322954002771
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