Journal article
International Assessment of Event-Free Survival at 24 Months and Subsequent Survival in Peripheral T-Cell Lymphoma
Journal of clinical oncology, Vol.35(36), pp.4019-4026
12/20/2017
DOI: 10.1200/JCO.2017.73.8195
PMCID: PMC5736237
PMID: 29072976
Abstract
Purpose Peripheral T-cell lymphomas (PTCLs) have aggressive clinical behavior. We have previously shown that event-free survival (EFS) at 24 months (EFS24) is a clinically useful end point in diffuse large B-cell lymphoma. Here, we assess EFS24 and subsequent overall survival (OS) in large, multinational PTCL cohorts. Patients and Methods Patients with systemic PTCL newly diagnosed from 2000 to 2012 and treated with curative intent were included from the United States and Sweden (initial cohorts) and from Canada (replication cohort). EFS was defined as time from date of diagnosis to progression after primary treatment, retreatment, or death. Subsequent OS was measured after achieving EFS24 or from the time of progression if it occurred within 24 months. OS rates were compared with the age-, sex-, and country-matched general population. Results Seven hundred seventy-five patients were included in the study (the median age at diagnosis was 64 years; 63% were men). Results were similar in the initial and replication cohorts, and a combined analysis was undertaken. Sixty-four percent of patients progressed within the first 24 months and had a median OS of only 4.9 months (5-year OS, 11%). In contrast, median OS after achieving EFS24 was not reached (5-year OS, 78%), although relapses within 5 years of achieving EFS24 occurred in 23% of patients. Superior outcomes after achieving EFS24 were observed in younger patients (≤ 60 years of age: 5-year OS, 91%). Conclusion EFS24 stratifies subsequent outcome in PTCL. Patients with PTCL with primary refractory disease or early relapse have extremely poor survival. However, more than one third of patients with PTCL remain in remission 2 years after diagnosis with encouraging subsequent OS, especially in younger patients. These marked differences in outcome suggest that EFS24 has utility for patient counseling, study design, and risk stratification in PTCL.
Details
- Title: Subtitle
- International Assessment of Event-Free Survival at 24 Months and Subsequent Survival in Peripheral T-Cell Lymphoma
- Creators
- Matthew J MaurerFredrik Ellin - Onkologi och Patologi, KampradlabLine Srour - University of British ColumbiaMats Jerkeman - Lymfom - Klinisk forskningN Nora Bennani - Mayo ClinicJoseph M Connors - University of British ColumbiaGraham W Slack - University of British ColumbiaKarin E Smedby - Karolinska InstitutetStephen M Ansell - Mayo ClinicBrian K Link - University of IowaJames R CerhanThomas Relander - Onkologi och Patologi, KampradlabKerry J Savage - University of British ColumbiaAndrew L Feldman - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Journal of clinical oncology, Vol.35(36), pp.4019-4026
- DOI
- 10.1200/JCO.2017.73.8195
- PMID
- 29072976
- PMCID
- PMC5736237
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Grant note
- U01 CA195568 / NCI NIH HHS R01 CA177734 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P30 CA015083 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
- Language
- English
- Date published
- 12/20/2017
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984360148002771
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