Journal article
International perspective on management of a patent ductus arteriosus: Lessons learned
Seminars in fetal & neonatal medicine, Vol.23(4), pp.278-284
08/2018
DOI: 10.1016/j.siny.2018.03.002
PMID: 29534972
Abstract
Whereas association between a patent ductus arteriosus (PDA) and neonatal morbidities has been well described, consensus has not been reached on whether the relationship is causal, on benefit of (or lack of) treatment, on factors guiding the ‘need to treat’, and on treatment strategies. Trials to date have primarily focused on the narrow outcome of successful ductal closure. Evidence from several retrospective studies has suggested that management may be modified with increased use of conservative treatment. A paradigm shift has resulted in decreased use of treatments to close the PDA in some centres. This approach cites the lack of demonstrable improvement in short- and long-term respiratory and neurodevelopmental outcomes as an argument. This article reviews current understanding of the wide variation in practice at either institutional, regional, national, or international level. It discusses the potential contributors to variability in diagnostic ascertainment and therapeutic intervention.
Details
- Title: Subtitle
- International perspective on management of a patent ductus arteriosus: Lessons learned
- Creators
- Arvind Sehgal - Monash Newborn, Monash Children's Hospital, Melbourne, AustraliaPatrick J McNamara - Department of Paediatrics, University of Toronto, Toronto, Canada
- Resource Type
- Journal article
- Publication Details
- Seminars in fetal & neonatal medicine, Vol.23(4), pp.278-284
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.siny.2018.03.002
- PMID
- 29534972
- ISSN
- 1744-165X
- eISSN
- 1878-0946
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984093320702771
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