International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery

Arne G Lindgren; Robynne G Braun; Jennifer Juhl  Majersik; Philip Clatworthy; Shraddha Mainali; Colin P Derdeyn; Jane Maguire; Christina Jern; Jonathan Rosand; John W Cole; Jin-Moo Lee; Pooja Khatri; Paul Nyquist; Stéphanie Debette; Loo Keat  Wei; Tatjana Rundek; Dana Leifer; Vincent Thijs; Robin Lemmens; Laura Heitsch; Kameshwar Prasad; Jordi Jimenez Conde; Martin Dichgans; Natalia S Rost; Steven C Cramer; Julie Bernhardt; Bradford B Worrall; Israel Fernandez-Cadenas

doi:10.1177/17474930211007288

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International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery

Journal article

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International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery

Arne G Lindgren, Robynne G Braun, Jennifer Juhl Majersik, Philip Clatworthy, Shraddha Mainali, Colin P Derdeyn, Jane Maguire, Christina Jern, Jonathan Rosand, John W Cole, …

International journal of stroke, Vol.17(3), pp.260-268

04/26/2021

DOI: 10.1177/17474930211007288

PMCID: PMC8864333

PMID: 33739214

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Abstract

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.

Genetics

Phenotype

Data collection

standardization

recovery

ischemic stroke

outcome

Details

Title: Subtitle: International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery
Creators: Arne G Lindgren - Department of Neurology, Skåne University Hospital, Lund, Sweden
Robynne G Braun - Department of Neurology, University of Maryland, Baltimore, MD, USA
Jennifer Juhl Majersik - Department of Neurology, University of Utah, Salt Lake City, UT, USA
Philip Clatworthy - Department of Neurology, North Bristol NHS Trust, Bristol, UK
Shraddha Mainali - Department of Neurology, 2647-->The Ohio State University, Columbus, OH, USA
Colin P Derdeyn - Department of Radiology, University of Iowa, Iowa City, IA, USA
Jane Maguire - Faculty of Health, University of Technology Sydney, Ultimo, NSW, Australia
Christina Jern - Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden
Jonathan Rosand - Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
John W Cole - Department of Neurology, 12264-->University of Maryland School of Medicine, Baltimore, MD, USA
Jin-Moo Lee - Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
Pooja Khatri - Department of Neurology and Rehabilitation Sciences, University of Cincinnati, Cincinnati, OH, USA
Paul Nyquist - Neurology, Anesthesiology/Critical Care Medicine, Neurosurgery, and General Internal Medicine, 1500-->Johns Hopkins School of Medicine, Baltimore, MD, USA
Stéphanie Debette - Neurology Department, Bordeaux University Hospital, Bordeaux, France
Loo Keat Wei - Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak, Malaysia
Tatjana Rundek - Department of Neurology, 12235-->University of Miami Miller School of Medicine, Miami, FL, USA
Dana Leifer - Department of Neurology, Weill Cornell Medicine, New York, NY, USA
Vincent Thijs - Stroke Theme, Florey Institute of Neuroscience and Mental Health, Melbourne, Vic, Australia
Robin Lemmens - Department of Neurology, University Hospitals Leuven, Leuven, Belgium
Laura Heitsch - Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
Kameshwar Prasad - Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Jordi Jimenez Conde - Neurology, Universitat Autònoma de Barcelona, Barcelona, Spain
Martin Dichgans - Institute for Stroke and Dementia Research, University Hospital, LMU, Munich, Germany
Natalia S Rost - Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Steven C Cramer - California Rehabilitation Institute, Los Angeles, CA, USA
Julie Bernhardt - Stroke Theme, Florey Institute of Neuroscience and Mental Health, Melbourne, Vic, Australia
Bradford B Worrall - Department of Neurology, University of Virginia, Charlottesville, VA, USA
Israel Fernandez-Cadenas - Stroke Pharmacogenomics and Genetics Group, Sant Pau Biomedical Research Institute, Barcelona, Spain
Resource Type: Journal article
Publication Details: International journal of stroke, Vol.17(3), pp.260-268
DOI: 10.1177/17474930211007288
PMID: 33739214
PMCID: PMC8864333
NLM abbreviation: Int J Stroke
eISSN: 1747-4949
Publisher: United States
Grant note: K12 HD093427 / NICHD NIH HHS
Language: English
Date published: 04/26/2021
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984071636702771

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