Interocular asymmetry of foveal avascular zone morphology and parafoveal capillary density in sickle cell retinopathy

Davis B Zhou; Adrienne W Scott; Marguerite O Linz; Ian C Han; Maria V Castanos; Giselle Lynch; Jorge S Andrade Romo; Rachel E Linderman; Joseph Carroll; Richard B Rosen; Toco Y Chui

doi:10.1371/journal.pone.0234151

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Interocular asymmetry of foveal avascular zone morphology and parafoveal capillary density in sickle cell retinopathy

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Interocular asymmetry of foveal avascular zone morphology and parafoveal capillary density in sickle cell retinopathy

Davis B Zhou, Adrienne W Scott, Marguerite O Linz, Ian C Han, Maria V Castanos, Giselle Lynch, Jorge S Andrade Romo, Rachel E Linderman, Joseph Carroll, Richard B Rosen, …

PloS one, Vol.15(6), pp.e0234151-e0234151

06/01/2020

DOI: 10.1371/journal.pone.0234151

PMCID: PMC7286490

PMID: 32520956

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Abstract

Objectives To examine interocular asymmetry of foveal avascular zone (FAZ) and parafoveal capillary density metrics in sickle cell retinopathy (SCR) using optical coherence tomography angiography (OCT-A). Methods This cross-sectional, retrospective study evaluated SCR patients and unaffected controls who underwent 3x3mm macular OCT-A imaging using a spectral domain-OCT system. FAZ (area, perimeter, and acircularity index) and parafoveal capillary density metrics were computed for both eyes of each participant. In unaffected controls, interocular difference in FAZ and parafoveal capillary density metrics were evaluated using Bland-Altman plots. SCR patients with interocular difference outside the upper 97.5% and lower 2.5% limits of agreement from controls were defined as having interocular asymmetry. Area under receiver operating characteristic curve (AROC) was also performed to determine the ability of the absolute interocular difference to differentiate between subjects with SCR—including non-proliferative SCR (NP-SCR) and proliferative SCR (P-SCR)–and unaffected controls. Results Thirty-one patients with SCR (21 NP-SCR and 10 P-SCR) and 14 race-matched and age-matched controls were included for analysis. Interocular asymmetry was seen for all FAZ and parafoveal capillary density metrics in NP-SCR and P-SCR subjects. SCR subjects showed greater disease severity in the left-eye for FAZ and parafoveal capillary density metrics. Conclusions NP-SCR and P-SCR patients demonstrated quantifiable interocular asymmetry in FAZ and parafoveal capillary density metrics compared to unaffected subjects, with left-eye predominance in disease severity.

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Title: Subtitle: Interocular asymmetry of foveal avascular zone morphology and parafoveal capillary density in sickle cell retinopathy
Creators: Davis B Zhou - Icahn School of Medicine at Mount Sinai
Adrienne W Scott - Johns Hopkins University
Marguerite O Linz - Johns Hopkins University
Ian C Han - University of Iowa
Maria V Castanos - New York Eye and Ear Infirmary
Giselle Lynch - Icahn School of Medicine at Mount Sinai
Jorge S Andrade Romo
Rachel E Linderman - Medical College of Wisconsin
Joseph Carroll - Medical College of Wisconsin
Richard B Rosen - Icahn School of Medicine at Mount Sinai
Toco Y Chui - Icahn School of Medicine at Mount Sinai
Resource Type: Journal article
Publication Details: PloS one, Vol.15(6), pp.e0234151-e0234151
DOI: 10.1371/journal.pone.0234151
PMID: 32520956
PMCID: PMC7286490
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science
Grant note: ; R01EY024969 / ; R01EY027301 / ;
Alternative title: Interocular asymmetry in sickle cell retinopathy
Language: English
Date published: 06/01/2020
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984181079002771

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