Interplay between tight junctions & adherens junctions

Hannah K Campbell; Jessica L Maiers; Kris A DeMali

doi:10.1016/j.yexcr.2017.03.061

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Interplay between tight junctions & adherens junctions

Journal article

Peer reviewed

Interplay between tight junctions & adherens junctions

Hannah K Campbell, Jessica L Maiers and Kris A DeMali

Experimental cell research, Vol.358(1), pp.39-44

09/01/2017

DOI: 10.1016/j.yexcr.2017.03.061

PMCID: PMC5544570

PMID: 28372972

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https://www.ncbi.nlm.nih.gov/pmc/articles/5544570View

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Abstract

Cell-cell adhesions are critical for the development and maintenance of tissues. Present at sites of cell-cell contact are the adherens junctions and tight junctions. The adherens junctions mediate cell-cell adhesion via the actions of nectins and cadherins. The tight junctions regulate passage of ions and small molecules between cells and establish cell polarity. Historically, the adherens and tight junctions have been thought of as discrete complexes. However, it is now clear that a high level of interdependency exists between the two junctional complexes. The adherens junctions and tight junctions are physically linked, by the zonula occludens proteins, and linked via signaling molecules including several polarity complexes and actin cytoskeletal modifiers. This review will first describe the individual components of both the adherens and tight junctions and then discuss the coupling of the two complexes with an emphasis on the signaling links and physical interactions between the two junctional complexes.

Tight Junctions - metabolism

Animals

Cadherins - metabolism

Humans

Cytoskeleton - metabolism

Cell Polarity - physiology

Cell Membrane - metabolism

Adherens Junctions - metabolism

Details

Title: Subtitle: Interplay between tight junctions & adherens junctions
Creators: Hannah K Campbell - Department of Biochemistry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Jessica L Maiers - Department of Biochemistry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Kris A DeMali - Department of Biochemistry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: kris-demali@uiowa.edu
Resource Type: Journal article
Publication Details: Experimental cell research, Vol.358(1), pp.39-44
DOI: 10.1016/j.yexcr.2017.03.061
PMID: 28372972
PMCID: PMC5544570
NLM abbreviation: Exp Cell Res
ISSN: 0014-4827
eISSN: 1090-2422
Publisher: United States
Grant note: R01 GM112805 / NIGMS NIH HHS P30 CA086862 / NCI NIH HHS
Language: English
Date published: 09/01/2017
Academic Unit: Dermatology; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
Record Identifier: 9984024411802771

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