Interplay of brain structure and function in neonatal congenital heart disease

Ala Birca; Vasily A. Vakorin; Prashob Porayette; Sujana Madathil; Vann Chau; Mike Seed; Sam M. Doesburg; Susan Blaser; Dragos A. Nita; Rohit Sharma; Emma G. Duerden; Edward J. Hickey; Steven P. Miller; Cecil D. Hahn

doi:10.1002/acn3.336

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Interplay of brain structure and function in neonatal congenital heart disease

Journal article

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Peer reviewed

Interplay of brain structure and function in neonatal congenital heart disease

Ala Birca, Vasily A. Vakorin, Prashob Porayette, Sujana Madathil, Vann Chau, Mike Seed, Sam M. Doesburg, Susan Blaser, Dragos A. Nita, Rohit Sharma, …

Annals of clinical and translational neurology, Vol.3(9), pp.708-722

09/2016

DOI: 10.1002/acn3.336

PMCID: PMC5018583

PMID: 27648460

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Abstract

Objective To evaluate whether structural and microstructural brain abnormalities in neonates with congenital heart disease (CHD) correlate with neuronal network dysfunction measured by analysis of EEG connectivity. Methods We studied a prospective cohort of 20 neonates with CHD who underwent continuous EEG monitoring before surgery to assess functional brain maturation and network connectivity, structural magnetic resonance imaging (MRI) to determine the presence of brain injury and structural brain development, and diffusion tensor MRI to assess brain microstructural development. Results Neonates with MRI brain injury and delayed structural and microstructural brain development demonstrated significantly stronger high‐frequency (beta and gamma frequency band) connectivity. Furthermore, neonates with delayed microstructural brain development demonstrated significantly weaker low‐frequency (delta, theta, alpha frequency band) connectivity. Neonates with brain injury also displayed delayed functional maturation of EEG background activity, characterized by greater background discontinuity. Interpretation These data provide new evidence that early structural and microstructural developmental brain abnormalities can have immediate functional consequences that manifest as characteristic alterations of neuronal network connectivity. Such early perturbations of developing neuronal networks, if sustained, may be responsible for the persistent neurocognitive impairment prevalent in adolescent survivors of CHD. These foundational insights into the complex interplay between evolving brain structure and function may have relevance for a wide spectrum of neurological disorders manifesting early developmental brain injury.

Details

Title: Subtitle: Interplay of brain structure and function in neonatal congenital heart disease
Creators: Ala Birca - Université de Montréal
Vasily A. Vakorin - Simon Fraser University
Prashob Porayette - University of Toronto
Sujana Madathil - Mental Health Research Institute
Vann Chau - University of Toronto
Mike Seed - University of Toronto
Sam M. Doesburg - Simon Fraser University
Susan Blaser - Hospital for Sick Children
Dragos A. Nita - University of Toronto
Rohit Sharma - University of Toronto
Emma G. Duerden - Mental Health Research Institute
Edward J. Hickey - University of Toronto
Steven P. Miller - University of Toronto
Cecil D. Hahn - University of Toronto
Resource Type: Journal article
Publication Details: Annals of clinical and translational neurology, Vol.3(9), pp.708-722
DOI: 10.1002/acn3.336
PMID: 27648460
PMCID: PMC5018583
NLM abbreviation: Ann Clin Transl Neurol
ISSN: 2328-9503
eISSN: 2328-9503
Number of pages: 15
Grant note: Canadian Institutes of Health Research (CIHR) (MOP93780) Royal College of Physicians and Surgeons of Canada CHU Sainte‐Justine/Group Aldo
Language: English
Date published: 09/2016
Academic Unit: Cardiology; Stead Family Department of Pediatrics; Neurology (Pediatrics); Internal Medicine
Record Identifier: 9984353824602771

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