Journal article
Interrater agreement in the assessment of motor manifestations of Huntington's disease
Movement disorders, Vol.20(3), pp.293-297
03/2005
DOI: 10.1002/mds.20332
PMID: 15584032
Abstract
With prospects improving for experimental therapeutics aimed at postponing the onset of illness in preclinical carriers of the Huntington's disease (HD) gene, we assessed agreement among experienced clinicians with respect to the motor manifestations of HD, a relevant outcome measure for preventive trials in this population. Seventy-five clinicians experienced in the evaluation of patients with early HD and six non-clinicians were shown a videotape compiled from the film archives of the United States–Venezuela Collaborative HD Research Project. Observers were asked to rate a 2–3-minute segment of the motor examination for each of 17 at-risk subjects. The rating scale ranged from 0 (normal) to 4 (unequivocal extrapyramidal movement disorder characteristic of HD). As measured by a weighted κ statistic, there was substantial agreement among the 75 clinicians in the judgment of unequivocal motor abnormalities comparing scale ratings of 4 with ratings that were not 4 (weighted κ = 0.67; standard error (SE) = 0.09). Agreement among the non-clinicians was only fair (weighted κ = 0.28; SE = 0.10). Even under the artificial conditions of a videotape study, experienced clinicians show substantial agreement about the signs that constitute the motor manifestations of illness in subjects at risk for HD. We expect these findings to translate to a similar level of interobserver agreement in the clinical trial setting involving experienced investigators examining live patients
Details
- Title: Subtitle
- Interrater agreement in the assessment of motor manifestations of Huntington's disease
- Creators
- Penelope Hogarth - Oregon Health & Science UniversityElise Kayson - University of RochesterKarl Kieburtz - University of RochesterKaren Marder - Columbia UniversityDavid Oakes - University of RochesterDiana Rosas - Harvard UniversityIra Shoulson - University of RochesterNancy S. Wexler - Columbia UniversityAnne B. Young - Harvard UniversityHongwei Zhao - University of RochesterUnited States–Venezuela Huntington's Disease Collaborative Research GroupHuntington Study Group
- Contributors
- Jane S Paulsen (Contributor) - University of Iowa, Psychological and Brain Sciences
- Resource Type
- Journal article
- Publication Details
- Movement disorders, Vol.20(3), pp.293-297
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/mds.20332
- PMID
- 15584032
- ISSN
- 0885-3185
- eISSN
- 1531-8257
- Number of pages
- 5
- Language
- English
- Date published
- 03/2005
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984383896902771
Metrics
5 Record Views