Journal article
Interrelationships between tuberculosis and chronic obstructive pulmonary disease
Current opinion in pulmonary medicine, Vol.29(2), pp.104-111
01/18/2023
DOI: 10.1097/MCP.0000000000000938
PMCID: PMC9877200
PMID: 36647566
Abstract
Our objective was to review the current literature regarding socioeconomic, environmental, clinical, and immunologic factors common to chronic obstructive pulmonary disease (COPD) and tuberculosis (TB).
Recent studies suggest that TB patients might be at increased risk for developing COPD. Conversely, additional prospective cohort studies have determined that COPD patients are at increased risk for active TB: a risk that appears to be partially mediated through inhaled corticosteroid use. Tobacco smoking, poverty, air pollution, and malnutrition are associated with COPD and TB. Vitamin D has been shown to prevent COPD exacerbations, but its use for preventing TB infection remains unclear. Surfactant deficiency, elevated matrix metalloproteinases, and toll-like receptor 4 polymorphisms play key roles in the pathogenesis of both diseases.
Recent studies have elucidated interrelationships between COPD and TB. Future research is needed to optimize clinical and public health approaches that could mitigate risk factors contributing to both diseases.
Details
- Title: Subtitle
- Interrelationships between tuberculosis and chronic obstructive pulmonary disease
- Creators
- Michael J Zavala - University of IowaGreta L BeckerRobert J Blount
- Resource Type
- Journal article
- Publication Details
- Current opinion in pulmonary medicine, Vol.29(2), pp.104-111
- DOI
- 10.1097/MCP.0000000000000938
- PMID
- 36647566
- PMCID
- PMC9877200
- NLM abbreviation
- Curr Opin Pulm Med
- ISSN
- 1070-5287
- eISSN
- 1531-6971
- Language
- English
- Date published
- 01/18/2023
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984361730302771
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