Journal article
Interruption of the Maintenance Phase Of Established Hypertension by Ablation of the Anteroventral Third Ventricle (AV3V) in Rats
Clinical and experimental hypertension (1993), Vol.1(3), pp.337-353
1978
DOI: 10.3109/10641967809068612
PMID: 756372
Abstract
Ablation of tissue surrounding anteroventral third ventricle (AV3V) was studied in three models of hypertensive rats. Lesions were placed in the AV3V at one and six weeks following the initiation of one kidney Grollman renal hypertension. At one week the rise in blood pressure was arrested and water intake was reduced; at six weeks arterial pressure returned to prehypertensive levels in animals surviving the post-lesion hydrational crisis. In two kidney (one clip) Goldblatt animals lesioned two weeks post-clip, arterial pressure was significantly reduced but did not become fully normotensive. Finally, the AV3V was also lesioned in spontaneously hypertensive rats (SHR-Okamoto strain) with established hypertension. The lesion did not reduce arterial pressure in adult SHR although characteristic initial adipsia and weight loss occurred. Ablation of the AV3V thus altered the course of maintenance of renal hypertension; however, the arterial pressure of SHR was not affected.
Details
- Title: Subtitle
- Interruption of the Maintenance Phase Of Established Hypertension by Ablation of the Anteroventral Third Ventricle (AV3V) in Rats
- Creators
- J Buggy - 1Departments of Pharmacology and Psychology and Cardiovascular Center, The University of Iowa, Iowa City, Iowa, 52242G. D Fink - 1Departments of Pharmacology and Psychology and Cardiovascular Center, The University of Iowa, Iowa City, Iowa, 52242J. R Haywood - 1Departments of Pharmacology and Psychology and Cardiovascular Center, The University of Iowa, Iowa City, Iowa, 52242A. K Johnson - 1Departments of Pharmacology and Psychology and Cardiovascular Center, The University of Iowa, Iowa City, Iowa, 52242M. J Brody - 1Departments of Pharmacology and Psychology and Cardiovascular Center, The University of Iowa, Iowa City, Iowa, 52242
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental hypertension (1993), Vol.1(3), pp.337-353
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/10641967809068612
- PMID
- 756372
- ISSN
- 1064-1963
- eISSN
- 1525-6006
- Language
- English
- Date published
- 1978
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213429402771
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