Journal article
Intersections Between Mitochondrial Metabolism and Redox Biology Mediate Posttraumatic Osteoarthritis
Current rheumatology reports, Vol.23(5), pp.32-32
04/24/2021
DOI: 10.1007/s11926-021-00994-z
PMID: 33893892
Abstract
Purpose of Review
This review will cover foundational studies and recent findings that established key concepts for understanding the importance of redox biology to chondrocyte mitochondrial function and osteoarthritis pathophysiology after injury.
Recent Findings
Articular chondrocyte mitochondria can be protected with a wide variety of antioxidants that will be discussed within a framework suggested by classic studies. These agents not only underscore the importance of thiol metabolism and associated redox function for chondrocyte mitochondria but also suggest complex interactions with signal transduction pathways and other molecular features of osteoarthritis that require more thorough investigation. Emerging evidence also indicates that reductive stress could occur alongside oxidative stress.
Summary
Recent studies have shed new light on historic paradoxes in chondrocyte redox and mitochondrial physiology, leading to the development of promising disease-modifying therapies for posttraumatic osteoarthritis.
Details
- Title: Subtitle
- Intersections Between Mitochondrial Metabolism and Redox Biology Mediate Posttraumatic Osteoarthritis
- Creators
- Piedad C Gomez-Contreras - University of IowaPaige N Kluz - University of IowaMadeline R Hines - University of IowaMitchell C Coleman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Current rheumatology reports, Vol.23(5), pp.32-32
- Publisher
- Springer US
- DOI
- 10.1007/s11926-021-00994-z
- PMID
- 33893892
- ISSN
- 1523-3774
- eISSN
- 1534-6307
- Grant note
- AR070914 / National Institute of Arthritis and Musculoskeletal and Skin Diseases (http://dx.doi.org/10.13039/100000069)
- Language
- English
- Date published
- 04/24/2021
- Academic Unit
- Orthopedics and Rehabilitation; Radiation Oncology
- Record Identifier
- 9984242443602771
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