Intersections between mitochondrial sirtuin signaling and tumor cell metabolism

Karina N. Gonzalez Herrera; Jaewon Lee; Marcia C. Haigis

doi:10.3109/10409238.2015.1031879

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Intersections between mitochondrial sirtuin signaling and tumor cell metabolism

Journal article

Peer reviewed

Intersections between mitochondrial sirtuin signaling and tumor cell metabolism

Karina N. Gonzalez Herrera, Jaewon Lee and Marcia C. Haigis

Critical reviews in biochemistry and molecular biology, Vol.50(3), pp.242-255

01/01/2015

DOI: 10.3109/10409238.2015.1031879

PMID: 25898275

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Abstract

Cancer cells use glucose and glutamine to facilitate cell growth and proliferation, a process coined "metabolic reprograming" - an emerging hallmark of cancer. Inside the cell, these nutrients synergize to produce metabolic building blocks, such as nucleic acids, lipids and proteins, as well as energy (ATP), glutathione and reducing equivalents (NADPH), required for survival, growth and proliferation. Intense research aimed at understanding the underlying cause of the metabolic rewiring has revealed that established oncogenes and tumor suppressors involved in signaling alter cellular metabolism to contribute to the transition from a normal quiescent cell to a rapidly proliferating cancer cell. Likewise, bona fide metabolic sensors are emerging as regulators of tumorigenesis. This review will focus on one such family of sensors, sirtuins, which utilize NAD + as a cofactor to catalyze deacetylation, deacylation and ADP-ribosylation of their protein substrates. In this review, we will enumerate how cancer cell metabolism is different from a normal quiescent cell and highlight the emerging role of mitochondrial sirtuin signaling in the regulation of tumor metabolism.

Antioxidants

glutamine metabolism

metabolic reprograming

signaling pathways

Warburg effect

Details

Title: Subtitle: Intersections between mitochondrial sirtuin signaling and tumor cell metabolism
Creators: Karina N. Gonzalez Herrera - Harvard Medical School
Jaewon Lee - Harvard University
Marcia C. Haigis - Harvard University
Resource Type: Journal article
Publication Details: Critical reviews in biochemistry and molecular biology, Vol.50(3), pp.242-255
DOI: 10.3109/10409238.2015.1031879
PMID: 25898275
ISSN: 1040-9238
eISSN: 1549-7798
Publisher: Informa Healthcare
Number of pages: 14
Language: English
Date published: 01/01/2015
Academic Unit: Surgery
Record Identifier: 9985240896602771

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