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Interstitial pulmonary disease and aluminum trihydrate exposure: A single case report and detailed workplace analysis
Journal article   Open access   Peer reviewed

Interstitial pulmonary disease and aluminum trihydrate exposure: A single case report and detailed workplace analysis

Claudia Corwin, Hillary Waterhouse, Jerrold L. Abraham, Soma Sanyal, Judith A. Crawford, Matthew Caddell and Michael J. Hodgson
American journal of industrial medicine, Vol.67(3), pp.274-286
03/2024
DOI: 10.1002/ajim.23564
PMID: 38253412
url
https://doi.org/10.1002/ajim.23564View
Published (Version of record) Open Access

Abstract

Abstract Exposure to aluminum compounds is clearly associated with pulmonary function decrements, and several animal models document possible mechanisms of aluminum‐ compound‐induced pulmonary toxicity. Nevertheless, disagreements remain about the precise mechanism by which exposures lead to damage. We present a strong case for attributing a case of interstitial pulmonary disease to occupational exposure to aluminum trihydrate. This report follows a 2014 publication of another case of interstitial pulmonary disease following a similar exposure. Our patient eventually underwent double lung transplantation nearly 5 years postexposure. Detailed pulmonary particulate elemental analysis suggested that aluminum metal, including aluminum trihydrate, was the most likely cause. A detailed assessment of the worker's relevant occupational exposures accompanies this case report.
UIOWA OA Agreement aluminum trihydrate Corian industrial occupational pulmonary disease

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