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Interstitial radiation in recurrent malignant gliomas
Journal article

Interstitial radiation in recurrent malignant gliomas

Patrick W Hitchon, Shirish K Jani, John C VanGilder, John C Godersky and Shirley Doornbos
Applied neurophysiology, Vol.50(1-6), pp.292-294
1987
DOI: 10.1159/000100729
PMID: 3329866

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Abstract

Twelve patients with recurrent supratentorial gliomas were treated with implanted 125I seeds. The interval from initial surgery to interstitial radiation ranged from 3 months to 9 years. The techniques for brachytherapy included volume implantation by craniotomy in one, stereotactic implantation with low-activity seeds in 7 and high-activity seeds in 4 patients. The total dose received ranged from 5,500 to 27,000 cGy. CT scans performed sequentially on all patients showed progressive attenuation in areas previously enhancing, suggestive of tumor necrosis produced by the interstitial sources. The mean and median survival of these patients was 23 and 22 weeks, with the 4 most recent patients still alive.
Astrocytoma - radiotherapy Neoplasm Recurrence, Local - radiotherapy Iodine Radioisotopes - therapeutic use Humans Middle Aged Adult Female Male Brachytherapy Brain Neoplasms - radiotherapy Glioma - radiotherapy Stereotaxic Techniques

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