Interstudy repeatability of self-gated quantitative myocardial perfusion MRI

Devavrat Likhite; Promporn Suksaranjit; Ganesh Adluru; Nan Hu; Cindy Weng; Eugene Kholmovski; Chris McGann; Brent Wilson; Edward DiBella

doi:10.1002/jmri.25107

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Interstudy repeatability of self-gated quantitative myocardial perfusion MRI

Journal article

Open access

Peer reviewed

Interstudy repeatability of self-gated quantitative myocardial perfusion MRI

Devavrat Likhite, Promporn Suksaranjit, Ganesh Adluru, Nan Hu, Cindy Weng, Eugene Kholmovski, Chris McGann, Brent Wilson and Edward DiBella

Journal of magnetic resonance imaging, Vol.43(6), pp.1369-1378

06/2016

DOI: 10.1002/jmri.25107

PMCID: PMC4865416

PMID: 26663511

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Abstract

To evaluate the interstudy repeatability of multislice quantitative cardiovascular magnetic resonance myocardial blood flow (MBF), myocardial perfusion reserve (MPR), and extracellular volume (ECV). A unique saturation recovery self-gated acquisition was used for the perfusion scans. An ungated golden angle radial turboFLASH pulse sequence was used to scan 10 subjects on two separate days on a 3T scanner. A single saturation pulse was followed by a set of four slices. Rest and hyperemia scans were acquired during free breathing. The images were reconstructed using an iterative algorithm with spatiotemporal constraints. The ungated images were retrospectively binned (self-gated) into near-systole and near-diastole. Deformable registration was performed to adjust for respiratory and residual cardiac motion, and the data were fit with a Fermi model to estimate the interstudy repeatability of quantitative self-gated MBF and MPR. The coefficient of variation (CoV) of the territorial MPR using the self-gated near-systole data was 18.6%. The self-gated near-diastole data gave less good CoV of MPR, equal to 46.2%. For MBFs, and using smaller (segmental) regions, the CoVs were 20.1% and 22.7% for the estimation of myocardial blood flow at stress and rest, respectively, using the self-gated near-systole data. The self-gated near-diastole data gave CoV = 48.6% and 44.9% for stress and rest. The self-gated free-breathing technique for quantification of myocardial blood flow showed good repeatability for near-systole, with results comparable to published studies on interstudy repeatability of quantitative myocardial perfusion MRI using ECG-gating and breath-holds. Self-gated near-diastole data results were less repeatable. J. Magn. Reson. Imaging 2016;43:1369-1378.

Blood Flow Velocity - physiology

Cardiac-Gated Imaging Techniques - methods

Coronary Artery Disease - diagnostic imaging

Coronary Artery Disease - physiopathology

Coronary Circulation - physiology

Female

Humans

Image Interpretation, Computer-Assisted - methods

Magnetic Resonance Angiography - methods

Magnetic Resonance Imaging, Cine - methods

Male

Middle Aged

Myocardial Perfusion Imaging - methods

Reproducibility of Results

Sensitivity and Specificity

Details

Title: Subtitle: Interstudy repeatability of self-gated quantitative myocardial perfusion MRI
Creators: Devavrat Likhite - University of Utah
Promporn Suksaranjit - University of Utah
Ganesh Adluru - University of Utah
Nan Hu - University of Utah
Cindy Weng - University of Utah
Eugene Kholmovski - University of Utah
Chris McGann - University of Utah
Brent Wilson - University of Utah
Edward DiBella - University of Utah
Resource Type: Journal article
Publication Details: Journal of magnetic resonance imaging, Vol.43(6), pp.1369-1378
DOI: 10.1002/jmri.25107
PMID: 26663511
PMCID: PMC4865416
NLM abbreviation: J Magn Reson Imaging
ISSN: 1053-1807
eISSN: 1522-2586
Grant note: R01 HL113224 / NHLBI NIH HHS
Language: English
Date published: 06/2016
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984359795802771

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